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Nanostructured TiO₂ Carbon Paste Based Sensor for Determination of Methyldopa
Luane Ferreira Garcia1, Carlos Eduardo Peixoto da Cunha2, Emily Kussmaul Gonçalves Moreno3
1Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, GO 74690-970, Brazil. luane.fg@hotmail.com.
Pharmaceuticals (Basel, Switzerland)
|October 11, 2018
Summary
A new, low-cost sensor using nanostructured titanium dioxide (TiO₂) modified carbon paste electrode (CPE) effectively detects methyldopa in pharmaceuticals. This reliable method enhances analytical sensitivity for accurate hypertension medication dosage.
Area of Science:
- Electroanalytical Chemistry
- Materials Science
- Pharmaceutical Analysis
Background:
- Accurate determination of methyldopa in pharmaceutical formulations is crucial for precise hypertension treatment.
- Existing analytical methods may lack cost-effectiveness or require complex procedures.
- Development of sensitive and reliable sensors for pharmaceutical analysis is an ongoing need.
Purpose of the Study:
- To develop a low-cost, nanostructured titanium dioxide-modified carbon paste electrode (TiO₂@CPE) for methyldopa detection.
- To evaluate the sensor's performance in determining methyldopa concentration in pharmaceutical samples.
- To assess the sensor's applicability and reliability for routine pharmaceutical analysis.
Main Methods:
- Modification of a carbon paste electrode (CPE) with nanostructured TiO₂.
- Characterization of the TiO₂-modified electrode using scanning electron microscopy (SEM) and X-ray diffraction (XRD).
- Electrochemical determination of methyldopa using differential pulse voltammetry (DPV) at pH 5.0.
Main Results:
- The TiO₂-modified graphite powder exhibited nanostructured morphology.
- The TiO₂@CPE sensor demonstrated enhanced sensitivity due to electro-catalytic effects.
- A linear response for methyldopa detection was observed between 10–180 μmol/L, with a Limit of Detection (LOD) of 1 μmol/L.
Conclusions:
- The developed TiO₂@CPE sensor is a cheap, reliable, and effective tool for methyldopa determination in pharmaceutical formulations.
- The sensor showed no interference from common pharmaceutical excipients.
- This strategy holds potential for the analysis of methyldopa and similar compounds in pharmaceutical samples.
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