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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy
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Advances in stem cell therapy for erectile dysfunction.

Serap Gur1,2, Asim B Abdel-Mageed1, Suresh C Sikka1

  • 1a Department of Urology , Tulane University Health Sciences Center , New Orleans , LA , USA.

Expert Opinion on Biological Therapy
|October 11, 2018
PubMed
Summary
This summary is machine-generated.

Stem cell (SC) therapy shows promise for treating erectile dysfunction (ED) by aiding in cavernous nerve regeneration and vascular recovery. Future clinical trials should focus on intracavernosal injection of a single SC type, with paracrine action as the primary mechanism.

Keywords:
Erectile dysfunctionagingcavernous nerve injurydiabetic ratstem cell

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Area of Science:

  • Regenerative Medicine
  • Urology
  • Stem Cell Biology

Background:

  • Erectile dysfunction (ED) is a significant health concern with various underlying causes.
  • Stem cell (SC) therapy is emerging as a potential treatment for ED and other sexual dysfunctions.
  • Research is expanding on SC applications in regenerative medicine for sexual health.

Purpose of the Study:

  • To review critical ED targets and preclinical studies involving SCs.
  • To analyze SC applications in animal models for conditions like diabetes, aging, and nerve injury.
  • To evaluate the potential of SC-based therapies for ED treatment.

Main Methods:

  • Literature search conducted on PubMed for English articles.
  • Inclusion of preclinical studies on SCs and animal models.
  • Focus on ED associated with diabetes, aging, cavernous nerve injury, and Peyronie's disease.

Main Results:

  • Combination treatments may be more effective than monotherapy for diabetic ED.
  • SC treatment shows potential for cavernous nerve regeneration and vascular recovery in ED.
  • Paracrine action, rather than cellular differentiation, is the likely primary mechanism of SCs in ED treatment.

Conclusions:

  • SC-based therapies hold promise for treating ED, particularly in conditions like post-prostatectomy ED.
  • Further research is needed to overcome hurdles before clinical application of SC therapies for ED.
  • Intracavernosal injection of a single SC type is suggested as the optimal protocol for future clinical trials.