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Updated: Feb 4, 2026

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
08:53

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma

Published on: June 10, 2017

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Classical pediatric Hodgkin lymphoma in very young patients: the Italian experience

Piero Farruggia1, Giuseppe Puccio2, Francesco Locatelli3

  • 1a Pediatric Hematology and Oncology Unit Oncology Department , A.R.N.A.S. Ospedali Civico Di Cristina e Benfratelli , Palermo , Italy.

Leukemia & Lymphoma
|October 11, 2018
PubMed

Insights

Younger children with classic Hodgkin lymphoma (cHL) have better outcomes. An age cutoff of 7 years identified low-risk pediatric patients, though age wasn't an independent factor.

Area of Science:

  • Pediatric Oncology
  • Hematology
  • Cancer Research

Background:

  • Younger patients with Hodgkin lymphoma (HL) often exhibit more favorable outcomes.
  • Identifying specific age-related risk factors is crucial for optimizing pediatric cancer treatment.

Purpose of the Study:

  • To determine an optimal age cutoff for identifying low-risk pediatric patients with classic Hodgkin lymphoma (cHL).
  • To characterize the natural history of classic Hodgkin lymphoma in very young patients.

Main Methods:

  • Retrospective analysis of 135 very young patients diagnosed with classic Hodgkin lymphoma.
  • Statistical evaluation to identify the best age cutoff for risk stratification.
  • Comparison of event-free survival (EFS) and progression-free survival (PFS) between age groups.

Main Results:

  • An age cutoff of 7 years was identified as optimal for distinguishing risk groups.
  • Significantly better EFS (p=.0451) and PFS (p=.00921) were observed in patients younger than 7 years.
  • Ten-year overall survival (OS) rates were 97.0% for younger patients versus 92.5% for older patients (p=.0448).

Conclusions:

  • While younger patients with cHL show better outcomes, age is not an independent prognostic factor.
  • The improved prognosis in younger children appears linked to more favorable initial disease characteristics.

Keywords:
Lymphoma and Hodgkin diseasechemotherapeutic approachespediatric

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