Related Experiment Video

Updated: Feb 4, 2026

Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression
09:06

Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression

Published on: February 3, 2023

2.0K

Far upstream element-binding protein 1 is up-regulated in pancreatic cancer and modulates immune response by

Ping Fan1, Jinlong Ma1, Xin Jin1

  • 1Department of Digestive Oncology Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Biochemical and Biophysical Research Communications
|October 11, 2018
PubMed

Insights

Far upstream element-binding protein 1 (FUBP1) is overexpressed in pancreatic cancer, promoting tumor growth and immune evasion by increasing PD-L1 expression. Targeting FUBP1 may overcome immunotherapy resistance in pancreatic cancer.

Area of Science:

  • Oncology
  • Cancer Immunology
  • Molecular Biology

Background:

  • Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer mortality with limited effective treatments.
  • Immune checkpoint inhibitors (ICIs) like anti-PD-L1 show potential but are often ineffective in PDAC.
  • PD-L1 expression is a key factor in ICI efficacy, necessitating understanding its regulation in pancreatic cancer.

Purpose of the Study:

  • To investigate the role of far upstream element-binding protein 1 (FUBP1) in pancreatic cancer.
  • To elucidate the mechanism by which FUBP1 influences tumor progression and immune evasion.
  • To explore FUBP1 as a potential therapeutic target for overcoming immunotherapy resistance in PDAC.

Main Methods:

  • Analysis of FUBP1 expression in pancreatic cancer tissues and correlation with prognosis.
  • Assessment of FUBP1's impact on pancreatic cancer cell proliferation and migration in vitro.
  • Investigation of FUBP1's role in regulating PD-L1 expression via the c-Myc pathway.

Main Results:

  • FUBP1 is overexpressed in pancreatic cancer and linked to poorer patient outcomes.
  • FUBP1 enhances pancreatic cancer cell proliferation and migration.
  • FUBP1 upregulates PD-L1 expression in pancreatic cancer cells, mediated by c-Myc, impacting cancer immunity.

Conclusions:

  • FUBP1 plays a significant role in pancreatic cancer progression and immune regulation.
  • FUBP1 promotes tumor growth and immune evasion by increasing PD-L1 expression through the Myc pathway.
  • Targeting FUBP1 presents a promising novel strategy to enhance immunotherapy efficacy in pancreatic cancer.
Keywords:
Far upstream element-binding protein 1 (FUBP1)Pancreatic ductal adenocarcinoma (PDAC)Programmed death ligand 1 (PD-L1)

More Related Videos

Overlapping Peptide Library to Map Qa-1 Epitopes in a Protein08:04

Overlapping Peptide Library to Map Qa-1 Epitopes in a Protein

Published on: December 20, 2017

7.4K
Author Spotlight: Exploring the Role of Unfolded Protein Response in HIV-1 Replication and Infectivity10:12

Author Spotlight: Exploring the Role of Unfolded Protein Response in HIV-1 Replication and Infectivity

Published on: June 14, 2024

2.6K

Related Concept Videos

Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
5.6K
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

4.1K
Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
15.1K
Ligand Binding Sites02:40

Ligand Binding Sites

8.8K
Regulated Protein Degradation02:58

Regulated Protein Degradation

It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
8.9K
Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
7.4K