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Association between fine particulate matter and oral cancer among Taiwanese men
Yu-Hua Chu1,2,3, Syuan-Wei Kao4, Disline Manli Tantoh4
1Department of Healthcare Administration, Asia University, Taichung City, Taiwan.
Abstract:
The aim of this study was to investigate the association between fine particulate matter 2.5 (PM2.5) and oral cancer among Taiwanese men. Four linked data sources including the Taiwan Cancer Registry, Adult Preventive Medical Services Database, National Health Insurance Research Database, and Air Quality Monitoring Database were used. Concentrations of sulfur dioxide, carbon monoxide, ozone, NOx (nitrogen monoxide and nitrogen dioxide), coarse particulate matter (PM10-2.5) and PM2.5 in 2009 were assessed in quartiles. A total of 482 659 men aged 40 years and above were included in the analysis. Logistic regression was used to examine the association between PM2.5 and oral cancer diagnosed from 2012 to 2013. After adjusting for potential confounders, the ORs of oral cancer were 0.91 (95% CI 0.75 to 1.11) for 26.74≤PM2.5<32.37, 1.01 (95% CI 0.84 to 1.20) for 32.37≤PM2.5<40.37 µg/m3 and 1.43 (95% CI 1.17 to 1.74) for PM2.5≥40.37 µg/m3 compared with PM2.5<26.74 µg/m3 In this study, there was an increased risk of oral cancer among Taiwanese men who were exposed to higher concentrations of PM2.5.
Insights
Exposure to fine particulate matter 2.5 (PM2.5) is linked to increased oral cancer risk in Taiwanese men. Higher PM2.5 concentrations correlated with a greater likelihood of developing oral cancer.
Area of Science:
- Environmental Health
- Oncology
- Epidemiology
Background:
- Air pollution, specifically fine particulate matter 2.5 (PM2.5), is a growing global health concern.
- Previous research suggests links between air pollutants and various cancers, but specific associations with oral cancer require further investigation.
Purpose of the Study:
- To investigate the association between exposure to fine particulate matter 2.5 (PM2.5) and the risk of oral cancer among Taiwanese men.
- To quantify the risk of oral cancer associated with different levels of PM2.5 exposure.
Main Methods:
- Utilized linked data from the Taiwan Cancer Registry, Adult Preventive Medical Services Database, National Health Insurance Research Database, and Air Quality Monitoring Database.
- Included 482,659 Taiwanese men aged 40+ years, assessing PM2.5 concentrations in 2009.
- Employed logistic regression to analyze the association between PM2.5 levels and oral cancer diagnoses from 2012-2013, adjusting for confounders.
Main Results:
- An increased risk of oral cancer was observed in men exposed to higher concentrations of PM2.5.
- Specifically, an odds ratio (OR) of 1.43 (95% CI 1.17 to 1.74) was found for PM2.5 concentrations ≥40.37 µg/m³ compared to the lowest quartile (<26.74 µg/m³).
Conclusions:
- Higher exposure to fine particulate matter 2.5 (PM2.5) is associated with an elevated risk of oral cancer in Taiwanese men.
- These findings highlight the potential impact of air quality on oral cancer incidence and underscore the need for pollution control measures.
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