Related Experiment Video
Updated: Feb 4, 2026
07:32
A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System
Published on: August 30, 2019
9.3K
Human Microbiome: Composition and Role in Inflammatory Skin Diseases
Anna Balato1, Sara Cacciapuoti2, Roberta Di Caprio3
1Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, NA, Italy.
Archivum Immunologiae Et Therapiae Experimentalis
|October 11, 2018
Summary
The human microbiome, encompassing gut and skin microbes, significantly impacts skin health. Its disruption is linked to inflammatory skin conditions like eczema and psoriasis, offering new avenues for personalized medicine.
Area of Science:
- Dermatology
- Microbiology
- Immunology
Background:
- The human microbiome plays a crucial role in maintaining health.
- Alterations in microbiome composition are increasingly implicated in various diseases.
- Specific focus on the gut and skin microbiome's connection to inflammatory skin conditions.
Purpose of the Study:
- To review recent evidence on human microbiome composition and function.
- To explore the link between microbiome impairment and inflammatory skin diseases.
- To examine the microbe-host dialogue and its health implications.
Main Methods:
- Analysis of current scientific literature.
- Focus on gut and skin microbiome composition.
- Examination of microbe-host and microbe-microbe interactions.
Main Results:
- Human microbes interact with different body sites, influencing immune activation and skin barrier.
- Microbiome dysbiosis is associated with atopic dermatitis, psoriasis, hidradenitis suppurativa, and acne.
- Factors affecting microbial activity can modulate chronic inflammatory skin diseases.
Conclusions:
- The human microbiome is pivotal in health and disease.
- Emerging insights suggest a role for microbiome modulation in managing inflammatory skin conditions.
- Future applications in personalized diagnostics, therapeutics, and prevention are anticipated.
Related Concept Videos
01:30Inflammatory Bowel Disease II: Crohn's Disease
1.1K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.1K
01:23Role of Skin in Vitamin D Synthesis
7.9K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
7.9K
01:23Skin Diseases and Disorders
5.4K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.4K
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
991
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
991
01:21Inflammatory Bowel Disease V: Surgical Management
523
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
523
01:29Inflammatory Bowel Disease IV: Pharmacological Management
610
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
610