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Proteinuria in children with autosomal dominant polycystic kidney disease

Tomáš Seeman1, Michael Pohl2, Ulrike John2

  • 1Section of Pediatric Nephrology, Department of Pediatrics - tomas.seeman@lfmotol.cuni.cz.

Minerva Pediatrica
|October 11, 2018
PubMed

Insights

Proteinuria is common in children with autosomal dominant polycystic kidney disease (ADPKD), with tubular proteinuria being the most frequent type. All children with ADPKD should be screened for proteinuria.

Area of Science:

  • Pediatric Nephrology
  • Genetics
  • Internal Medicine

Background:

  • Proteinuria is a known complication and progression risk factor in adult autosomal dominant polycystic kidney disease (ADPKD).
  • Proteinuria has been understudied in pediatric ADPKD, with its types remaining uninvestigated.
  • This study addresses the knowledge gap regarding proteinuria in children with ADPKD.

Purpose of the Study:

  • To determine the prevalence of proteinuria in children diagnosed with ADPKD.
  • To analyze the specific types of proteinuria present in pediatric ADPKD patients.
  • To establish baseline data for proteinuria in this population.

Main Methods:

  • A cross-sectional study was conducted on children with ADPKD from 2012-2013.
  • Morning urine samples were analyzed for total protein, albumin, and alpha-1-microglobulin.
  • Renal function was assessed using estimated glomerular filtration rate from serum creatinine.

Main Results:

  • Thirty-seven children (median age 11.2 years) were included.
  • Pathological total proteinuria was found in 30%, albuminuria in 49%, and alpha-1-microglobulinuria in 65%.
  • No significant correlations were observed between proteinuria markers and blood pressure, kidney size, or GFR.

Conclusions:

  • Proteinuria is a frequent finding in children with ADPKD.
  • Tubular proteinuria is the predominant type observed in this cohort.
  • Routine measurement of proteinuria is recommended for all children with ADPKD.
Abstract

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