Utilizing the electronic health record to construct antibiograms for previously healthy children with urinary tract...

Area of Science:

• Microbiology
• Pediatrics
• Infectious Diseases

Background:

• Standard antibiograms may not accurately reflect antibiotic resistance patterns in specific patient subpopulations.
• Urinary tract infections (UTIs) are common in children, necessitating precise treatment guidance.

Purpose of the Study:

• To develop and validate syndrome-specific antibiograms for previously healthy children with UTIs.
• To assess antibiotic susceptibility patterns within this defined pediatric cohort.

Main Methods:

• Retrospective descriptive study design.
• Utilized International Classification of Disease, Tenth Revision (ICD-10) codes and discrete data elements to define the study cohort.
• Constructed and validated custom antibiograms.

Main Results:

• The developed antibiograms indicated increased antibiotic susceptibility in the studied pediatric UTI population.
• Demonstrated the feasibility of creating tailored antibiograms for specific clinical syndromes.

Conclusions:

• Syndrome-specific antibiograms, like those developed for pediatric UTIs, offer a more precise approach to guiding empiric antibiotic therapy.
• This methodology holds potential for adaptation to create other syndrome-specific antibiograms for improved antimicrobial stewardship.