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Drug metabolism by the human hepatoma cell, Hep G2

S Sassa, O Sugita, R A Galbraith

Biochemical and Biophysical Research Communications

|February 27, 1987

Abstract:

The human liver-derived cell line, Hep G2, has aryl hydrocarbon hydroxylase and 7-ethoxycoumarin o-de-ethylase activities. Partial purification of cytochrome P-450 from Hep G2 cells provided spectral evidence of this hemeprotein in the purified fraction. These results suggest that Hep G2 cells will be useful for the study of cytochrome P-450 and the regulation of mixed function oxidase activities in liver cells of human origin.

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