[CYTOKINE PROFILE IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION WITH AND WITHOUT COMPLICATIONS]

Area of Science:

• Cardiology
• Immunology
• Biochemistry

Background:

• ST-segment elevation myocardial infarction (STEMI) is a critical cardiovascular event.
• Understanding prognostic markers is crucial for patient management and risk stratification.
• Cytokine profiles are increasingly recognized for their role in inflammatory processes post-MI.

Purpose of the Study:

• To investigate the prognostic significance of specific cytokines in patients with STEMI.
• To determine if cytokine levels can predict cardiovascular complications within one year of STEMI.
• To evaluate the role of IL-6, IL-1β, IL-10, TNFα, and CRP in STEMI prognosis.

Main Methods:

• Assessed cytokine (IL-6, IL-1β, IL-10, TNFα) and C-reactive protein (CRP) levels in 81 STEMI patients.
• Compared cytokine concentrations between patients with complicated and uncomplicated STEMI courses.
• Compared STEMI patient groups with a control group of healthy subjects.
• Monitored patients for cardiovascular complications within one year post-STEMI.

Main Results:

• Patients with complicated STEMI showed significantly higher concentrations of IL-6, IL-10, TNFα, and CRP on days 1, 7, and 14 compared to controls and uncomplicated STEMI patients.
• Specific elevated thresholds for TNFα (>35.49 pg/ml), IL-6 (>33.37 pg/ml), IL-10 (>34 pg/ml), and CRP (>10.84 mg/l) on day 1 were associated with increased cardiovascular complications within one year.
• No reliable prognostic levels for IL-1β were identified as its concentration remained within the normal range.

Conclusions:

• Initial elevations in blood CRP, TNFα, IL-6, and IL-10 levels are valuable indicators for identifying STEMI patients at high risk of cardiovascular events.
• These cytokine markers can aid in stratifying STEMI patients for closer monitoring and tailored therapeutic strategies.
• The study highlights the prognostic utility of specific inflammatory markers in the early phase of STEMI.