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Response to PCV13 vaccination in patients with multiple myeloma versus healthy controls

S Shahzad Mustafa1,2, Deep Shah1, Jonathan Bress1,3

  • 1a Department of Medicine , Rochester Regional Health , Rochester , NY , USA.

Human Vaccines & Immunotherapeutics
|October 11, 2018
PubMed

Insights

Multiple myeloma patients show a similar initial immune response to the pneumococcal conjugate vaccine (PCV13) compared to healthy individuals. However, the vaccine

Area of Science:

  • Immunology
  • Vaccinology
  • Hematology

Background:

  • Infections pose significant risks for multiple myeloma (MM) patients due to impaired immune function.
  • Humoral dysfunction in MM patients leads to inadequate responses to vaccines like the pneumococcal polysaccharide vaccine (PPV23).
  • The pneumococcal conjugate vaccine (PCV13), which induces a T-cell dependent immune response, is recommended for MM patients.

Purpose of the Study:

  • To compare the initial immune response to PCV13 in multiple myeloma patients versus healthy controls.
  • To assess the durability of the immune response to PCV13 at six months post-vaccination in both groups.

Main Methods:

  • Seven patients with multiple myeloma and 18 healthy controls were enrolled.
  • Streptococcal pneumonia serotype IgG titers were measured at baseline, day 30, and day 180 after PCV13 vaccination.

Main Results:

  • PCV13 vaccination elicited a comparable initial IgG titer response in multiple myeloma patients and control subjects.
  • The duration of the immune response to PCV13 appeared to diminish more rapidly in multiple myeloma patients compared to controls by day 180.

Conclusions:

  • While PCV13 provides an initial immune response in multiple myeloma patients, its long-term effectiveness may be compromised.
  • Further research is needed to understand and potentially improve the durability of PCV13 responses in immunocompromised individuals with multiple myeloma.
Keywords:
Multiple myelomaPCV13Vaccination

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