Jove
Visualize
Contact Us

Related Concept Videos

Insomnia01:27

Insomnia

477
Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
Multiple factors contribute...
477
Management of Insomnia01:19

Management of Insomnia

641
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
641
Blind Procedures02:07

Blind Procedures

13.4K
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
13.4K
The Placebo Effect01:54

The Placebo Effect

6.9K
The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
6.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Radioanatomy of the Silent Sinus Syndrome.

OTO open·2026
Same author

Buprenorphine Oral Lyophilisate for Treatment of Opioid Use Disorder: Pharmacology and Clinical Efficacy.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Allergic Rhinitis and Its Impact on Asthma (ARIA)-EAACI Guidelines-2024-2025 Revision: Part I-Guidelines on Intranasal Treatments.

Allergy·2025
Same author

Methodology for the Development of the Allergic Rhinitis and Its Impact on Asthma (ARIA)-EAACI 2024-2025 Guidelines: From Evidence-to-Decision Frameworks to Digitalised Shared Decision-Making Algorithms.

Allergy·2025
Same author

[Therapy of substance use disorders in correctional settings].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2025
Same author

Persisting high rates of mental health disorders in patients in opioid agonist treatment-Results from a 6-year longitudinal study.

The American journal on addictions·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Feb 4, 2026

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.6K

Eszopiclone for insomnia.

Susanne Rösner1, Christian Englbrecht, Renate Wehrle

  • 1Forel Klinik, Islikonerstrasse 5, Ellikon an der Thur, Switzerland, 8548.

The Cochrane Database of Systematic Reviews
|October 11, 2018
PubMed
Summary

Eszopiclone effectively reduces sleep onset latency and wake time while increasing total sleep time for insomnia patients. While generally safe when used as recommended, caution is advised for elderly individuals and those at risk of misuse.

More Related Videos

Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia
04:59

Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia

Published on: May 30, 2025

1.5K
Protocol for Microplastics Sampling on the Sea Surface and Sample Analysis
10:16

Protocol for Microplastics Sampling on the Sea Surface and Sample Analysis

Published on: December 16, 2016

50.9K

Related Experiment Videos

Last Updated: Feb 4, 2026

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.6K
Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia
04:59

Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia

Published on: May 30, 2025

1.5K
Protocol for Microplastics Sampling on the Sea Surface and Sample Analysis
10:16

Protocol for Microplastics Sampling on the Sea Surface and Sample Analysis

Published on: December 16, 2016

50.9K

Area of Science:

  • Pharmacology and Sleep Medicine
  • Clinical Trial Analysis
  • Public Health Research

Background:

  • Insomnia affects 6-10% of adults in Western countries, posing a significant public health challenge.
  • Eszopiclone, a new-generation hypnotic, is marketed for efficacy comparable to benzodiazepines but with improved safety and lower dependence risk.
  • This review integrates evidence from randomized controlled trials (RCTs) to evaluate eszopiclone's efficacy and safety, considering methodological quality and bias.

Purpose of the Study:

  • To assess the efficacy and safety of eszopiclone for insomnia treatment.
  • To compare eszopiclone's effects against placebo or active controls in randomized controlled trials.
  • To synthesize findings from existing literature, considering study quality and potential biases.

Main Methods:

  • Searched multiple databases (Cochrane CENTRAL, MEDLINE, Embase, PsycINFO, etc.) up to February 2016, with an update search in February 2018.
  • Included parallel-group RCTs comparing eszopiclone with placebo or active controls in adults with diagnosed insomnia (primary or comorbid).
  • Independent data extraction and quality assessment by two authors; meta-analysis of reported outcomes.

Main Results:

  • 14 RCTs with 4732 participants evaluated short-term, medium-term, and long-term eszopiclone use.
  • Eszopiclone showed moderate-quality evidence for improving sleep: reduced sleep onset latency (12 min), reduced wake time after sleep onset (17 min), and increased total sleep time (28 min) compared to placebo.
  • Adverse events more frequent with eszopiclone included unpleasant taste, dry mouth, somnolence, and dizziness; evidence quality for efficacy and adverse events was moderate, and low for rebound effects.

Conclusions:

  • Eszopiclone demonstrates moderate efficacy in improving sleep onset and maintenance for insomnia.
  • Evidence suggests minimal harm when eszopiclone is used as recommended.
  • Caution is advised for elderly individuals, those with cognitive/motor impairments, and individuals at risk of misuse due to potential adverse events and underrepresentation in trials.