Related Experiment Video

Updated: Feb 4, 2026

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy
14:18

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy

Published on: October 13, 2023

1.8K

Relationship between renal CD68+ infiltrates and the Oxford Classification of IgA nephropathy

Maria F Soares1, Vera Genitsch1,2, Aron Chakera3

  • 1Department of Cellular Pathology, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Histopathology
|October 11, 2018
PubMed

Insights

Glomerular CD68-positive cells are a reproducible marker for endocapillary hypercellularity in IgA nephropathy (IgAN), improving upon the Oxford Classification E score. Tubulointerstitial CD68 cells correlate with chronic kidney damage.

Area of Science:

  • Nephrology
  • Immunopathology
  • Renal Pathology

Background:

  • The Oxford Classification E score for endocapillary hypercellularity in IgA nephropathy (IgAN) predicts renal decline but has poor reproducibility.
  • Endocapillary hypercellularity is hypothesized to reflect glomerular inflammation.

Purpose of the Study:

  • To investigate if CD68-positive cells, a marker of inflammation, are a more robust indicator of endocapillary hypercellularity than the current Oxford Classification E score.
  • To assess the correlation between CD68-positive cells and other Oxford Classification criteria, and their association with renal function and chronic damage.

Main Methods:

  • Quantification of CD68-positive cells in glomeruli and tubulointerstitium from 118 IgAN patient biopsies.
  • Correlation analysis of CD68 counts with Oxford Classification criteria (E score, mesangial hypercellularity, segmental sclerosis, crescents, tubular atrophy/interstitial fibrosis).
  • Receiver operating characteristic (ROC) curve analysis to determine the optimal CD68 cut-off for E score, and assessment of reproducibility using kappa scores and image analysis.

Main Results:

  • A strong correlation was found between median glomerular CD68 count and the percentage of glomeruli with endocapillary hypercellularity (r=0.67, P<0.001).
  • A glomerular CD68 count >6 was identified as the optimal cut-off for distinguishing E0 from E1 (sensitivity 94.1%, specificity 71%).
  • Identification of biopsies with >6 glomerular CD68 counts was reproducible (kappa=0.8). Tubulointerstitial CD68 cells correlated with tubular atrophy/interstitial fibrosis (r=0.59) and GFR (r=0.54).

Conclusions:

  • Glomerular CD68-positive cells serve as reliable and reproducible markers for endocapillary hypercellularity in IgAN.
  • Tubulointerstitial CD68-positive cells are associated with chronic kidney damage, specifically tubular atrophy and interstitial fibrosis.
Abstract

Keywords:
IgA nephropathyglomerulonephritismacrophages

More Related Videos

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.5K
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

25.0K

Related Concept Videos

Relationship Formation02:12

Relationship Formation

What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...
46.2K
Ending Relationships01:28

Ending Relationships

The dissolution of intimate relationships presents complex emotional and psychological challenges, particularly when emotional bonds are strong, the relationship is long-standing, and perceived alternatives are limited. This distress often intensifies in romantic breakups, where the initiator may experience greater turmoil than the rejected partner. Contributing factors include residual attachment, guilt over causing pain, and uncertainty about how to manage the situation. The stress is further...
189
Relationship Growth01:27

Relationship Growth

Interpersonal relationships progress through stages, beginning with awareness and moving toward mutuality, where emotional connections deepen. While many relationships remain at moderate levels of mutuality, deeper connections form through self-disclosure, trust, and interdependence.Self-DisclosureSelf-disclosure involves revealing personal information, starting with surface-level details and gradually progressing to more intimate content. As trust grows, individuals feel more comfortable...
220
Social Relationships and Well-Being01:30

Social Relationships and Well-Being

The significance of social relationships in psychological well-being is a well-established area of inquiry within social psychology. Research consistently demonstrates that the presence of meaningful, supportive relationships enhances emotional health, while the absence or deterioration of such connections can contribute to psychological distress. Relationships serve as a foundation for emotional support, identity, and social belonging, all of which are critical to an individual’s overall...
311
Force Classification01:22

Force Classification

Forces play a crucial role in the study of physics and engineering. They are essential in describing the motion, behavior, and equilibrium of objects in the physical world. Forces can be classified based on their origin, type, and direction of action.
Contact and non-contact forces are two of the most widely used categories of forces. As the name suggests, contact forces require physical contact between two objects to act upon each other. Examples of contact forces include frictional,...
2.4K
Classification of Neurotransmitters01:30

Classification of Neurotransmitters

Neurotransmitters play a crucial role in the communication between neurons in the autonomic nervous system. Neurons in the autonomic nervous system can be cholinergic or adrenergic depending on the neurotransmitters synthesized. Cholinergic neurons use acetylcholine as their primary neurotransmitter. This includes all the preganglionic fibers of the sympathetic and pre- and postganglionic fibers of the parasympathetic nervous systems. In addition, neurons of the somatic nervous system also use...
5.3K