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Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

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[EVALUATION OF CARDIOVASCULAR RISKS WITH THE USE OF MORPHOGENETIC KLOTHO PROTEIN IN PATIENTS WITH CHRONIC RENAL

N A Mukhin, L Yu Milovanova, V V Fomin

Klinicheskaia Meditsina

|October 11, 2018

Summary

Klotho protein levels decrease early in chronic kidney disease (CKD), indicating cardiovascular risk. Angiotensin receptor blockers may help maintain Klotho levels in CKD patients.

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Area of Science:

Nephrology
Cardiology
Biochemistry

Background:

Chronic kidney disease (CKD) is associated with cardiovascular complications.
Klotho protein is implicated in aging and kidney function.
Understanding Klotho's role in CKD is crucial for risk assessment.

Purpose of the Study:

To investigate the significance of Klotho protein across different stages of CKD.
To evaluate the impact of antihypertensive therapy on serum Klotho levels.

Main Methods:

Study included 130 patients with stage 5 CKD.
Measured serum Klotho, PTH, calcium, phosphorus, and blood pressure.
Utilized ELISA, echocardiography, and vascular imaging techniques.

Main Results:

Serum Klotho decreased earlier than phosphate and PTH in CKD stages (starting from 3A).
Low Klotho (<387 pg/ml) predicted myocardial calcification risk (80% sensitivity, 76% specificity).
Angiotensin receptor blockers (ARB) were associated with higher Klotho levels compared to other antihypertensives or uncontrolled BP.

Conclusions:

Klotho protein serves as an early diagnostic marker for cardiovascular risk in CKD.
Reduced Klotho levels were less pronounced with ARB use for hypertension.
Normal Klotho levels correlate with lower cardiovascular calcification in CKD patients.