[MODERN CLINICAL EPIDEMIOLOGICAL CHARACTERISTIC OF LUPUS ERYTHEMATOSUS BASED ON THE DATA OF REGIONAL REGISTRY]

Area of Science:

• Rheumatology
• Epidemiology
• Clinical Medicine

Background:

• Systemic Lupus Erythematosus (SLE) is a complex rheumatic disease with a polysymptomatic presentation.
• Updated epidemiological data for SLE are scarce due to its low prevalence.
• Understanding current disease characteristics is crucial for effective management.

Purpose of the Study:

• To investigate the current clinical and epidemiological features of Systemic Lupus Erythematosus (SLE).
• To analyze the occurrence and early-stage symptoms of SLE using territorial register data.
• To compare observed symptoms with established diagnostic criteria.

Main Methods:

• Retrospective analysis of 107 SLE cases from 1980-2013.
• Evaluation of epidemiological situation using extensive and intensive indicators.
• Statistical analysis of prevalence, incidence, and demographic data.

Main Results:

• SLE prevalence estimated at 5.59 per 100,000 population in 2013.
• Incidence rates showed an increase from 0.29 to 0.49 per 100,000 population between 1994-2013.
• Female to male ratio was 9:1, mean age 37.62 years; early symptoms (polyarthritis, fever, dermatitis) differed from advanced (polyarthritis, Raynaud's, carditis, myalgia).

Conclusions:

• The study provides current epidemiological and clinical insights into Systemic Lupus Erythematosus (SLE).
• Observed early and advanced symptoms diverge from American College of Rheumatology criteria, indicating a need for re-evaluation.
• The findings support the proposal for classifying SLE into distinct clinical subtypes (phenotypes).