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Related Experiment Video

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Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
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Left ventricular diastolic dysfunction: identifying presence by left atrial function

Emily Worley1, Bushra Rana1, Lynne Williams1

  • 1Royal Papworth Hospital, Papworth Everard, Cambridgeshire, UK

Echo Research and Practice
|October 11, 2018
PubMed
Summary
This summary is machine-generated.

Left atrial ejection fraction (LAEF) and left atrial active emptying fraction (LAAEF) effectively identify diastolic dysfunction. A decline in these left atrial function metrics indicates worsening left ventricular diastolic dysfunction (LVDD).

Keywords:
echocardiographyleft ventriculardiastolic dysfuctionleft atrial function

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Area of Science:

  • Cardiology
  • Echocardiography
  • Cardiac Physiology

Background:

  • The left atrium (LA) is subjected to left ventricular pressure during diastole.
  • Left ventricular diastolic dysfunction (LVDD) is a significant clinical condition.
  • Assessing LVDD traditionally relies on echocardiographic parameters of diastolic function.

Purpose of the Study:

  • To investigate the utility of left atrial ejection fraction (LAEF) and left atrial active emptying fraction (LAAEF) as markers for LVDD.
  • To evaluate LAEF and LAAEF against established guidelines for left ventricular diastolic function (LVDF).

Main Methods:

  • Retrospective analysis of 124 patients undergoing transthoracic echocardiography.
  • Measurement of mitral inflow (MV E, MV A) and tissue Doppler (e′, E/e′) parameters.
  • Calculation of LAEF and LAAEF from atrial volumes and function.

Main Results:

  • LAEF and LAAEF demonstrated high diagnostic accuracy (AUC 0.826 and 0.861) for predicting LVDD.
  • These metrics showed a sensitivity of 85.5% and specificity of 78% for LVDD.
  • LAEF and LAAEF accurately predicted patients with an elevated E/e′ ratio (≥14).

Conclusions:

  • Reduced LAEF and LAAEF are associated with the presence and severity of LVDD.
  • LAEF and LAAEF serve as valuable indicators of diastolic dysfunction.
  • These left atrial function parameters offer a novel approach to LVDD assessment.