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Loss of Ovarian Hormones and Accelerated Somatic and Mental Aging
Walter A Rocca1,2,3, Liliana Gazzuola Rocca1, Carin Y Smith4
1Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic , Rochester, Minnesota.
Abstract:
Bilateral oophorectomy in premenopausal women is a unique condition causing the abrupt and premature loss of ovarian hormones, primarily estrogen. Bilateral oophorectomy causes an alteration of several fundamental aging processes at the cellular, tissue, organ, and system levels, leading to multimorbidity, frailty, and reduced survival. However, many questions remain unanswered.
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