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Hereditary Cancer Risk Assessment and Genetic Testing in the Community-Practice Setting.

Mark S DeFrancesco1, Richard N Waldman, Melissa M Pearlstone

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Summary
This summary is machine-generated.

Integrating hereditary cancer risk assessment into obstetrics and gynecology practices is feasible. This approach significantly increased genetic testing rates and identified important cancer risks in women.

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Area of Science:

  • Oncology
  • Genetics
  • Women's Health

Background:

  • Hereditary cancer syndromes pose significant risks.
  • Routine screening in community practices can improve early detection.

Purpose of the Study:

  • To assess the feasibility of integrating hereditary cancer risk assessment, counseling, and genetic testing into community obstetrics and gynecology settings.
  • To evaluate the impact of this integrated approach on genetic testing rates and identification of cancer risks.

Main Methods:

  • A prospective process intervention study was conducted in two obstetrics and gynecology practice groups.
  • The intervention involved training staff in hereditary cancer risk screening and refining patient workflows.
  • Outcomes were measured during an 8-week postintervention period, including assessment rates, genetic testing offers, completion rates, and patient/provider satisfaction.

Main Results:

  • 92.8% of patients were assessed for hereditary cancer risk.
  • Genetic testing completion rates increased fourfold postintervention (4.0% vs. 1.1%).
  • Pathogenic variants were identified in 5.5% of tested women, revealing significant, previously unrecognized cancer risks.

Conclusions:

  • Hereditary cancer risk assessment and genetic testing can be successfully integrated into community obstetrics and gynecology practices.
  • This integration leads to increased genetic testing uptake and identification of actionable cancer risks.
  • The process demonstrated high patient and healthcare provider satisfaction.