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Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI
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Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI

Published on: November 27, 2019

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Brain gray and white matter abnormalities in preterm-born adolescents: A meta-analysis of voxel-based morphometry

Le Zhou1,2, Youjin Zhao1, Xinghui Liu3

  • 1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, P.R. China.

Plos One
|October 11, 2018
PubMed

Insights

Preterm-born adolescents show widespread gray and white matter volume differences in key brain networks, impacting socialization and cognition. Male preterm adolescents exhibit a specific correlation between lower gray matter volume and sex.

Area of Science:

  • Neuroimaging
  • Developmental Neuroscience
  • Brain Anatomy

Background:

  • Voxel-based morphometry studies reveal inconsistent gray matter volume (GMV) and white matter volume (WMV) abnormalities in preterm-born adolescents (PBA).
  • Meta-analysis is crucial for identifying consistent structural brain alterations in this population.

Purpose of the Study:

  • To conduct a meta-analysis identifying consistent GMV and WMV alterations in PBA compared to healthy controls.
  • To explore potential correlations between demographic factors and observed brain structure differences.

Main Methods:

  • Systematic literature search identifying 9 eligible studies up to October 2017.
  • Seed-based d Mapping (SDM) used for meta-analysis of GMV and WMV data.
  • Meta-regression analysis to investigate correlations with PBA demographics.

Main Results:

  • PBA exhibited increased GMV in specific cortical regions (left cuneus, left superior frontal gyrus, right anterior cingulate) and decreased GMV in others (bilateral inferior temporal gyrus, right caudate nucleus).
  • WMV alterations in PBA included increased volume in the right fusiform gyrus and precuneus, and decreased volume in bilateral inferior temporal gyrus and right inferior frontal gyrus.
  • Meta-regression revealed a negative correlation between the percentage of male PBA and decreased GMV in the bilateral inferior temporal gyrus.

Conclusions:

  • PBA demonstrate widespread GMV and WMV alterations within the default mode, visual recognition, and salience networks.
  • These structural changes are potentially linked to observed socialization difficulties and cognitive impairments in PBA.
  • Meta-regression findings suggest a structural basis for sex-related cognitive differences in preterm-born individuals.
Abstract

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