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Applications for Open Source Microplate-Compatible Illumination Panels
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PlateDesigner: a web-based application for the design of microplate experiments.

Maria Suprun1, Mayte Suárez-Fariñas2,3

  • 1Department of Pediatrics, Allergy and Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Bioinformatics (Oxford, England)
|October 11, 2018
PubMed
Summary

Batch effects in biological assays can confound results. PlateDesigner is a new web tool that simplifies experimental design by randomizing samples in microplate assays, ensuring robust data analysis.

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Area of Science:

  • Biological assays
  • High-throughput technologies
  • Experimental design

Background:

  • Systematic variability, known as batch effects, can confound biological assay results.
  • Microplate-based multiplex experiments (e.g., Luminex, OLINK) require consideration of position and plate effects.
  • Proper experimental design, including sample randomization, is crucial for mitigating these effects.

Purpose of the Study:

  • Introduce PlateDesigner, the first web-based application for microplate experiment randomization.
  • Facilitate proper experimental design by ensuring sample grouping and balanced condition distribution.
  • Simplify the randomization process for researchers handling multiple samples.

Main Methods:

  • PlateDesigner is a web application developed using R/Shiny.
  • It provides randomization for microplate experiments.
  • The application ensures key experimental design principles are applied.

Main Results:

  • PlateDesigner offers a simple interface for creating randomizations.
  • Results can be exported in various formats.
  • The output is easily integrated with microplate readers and statistical software.

Conclusions:

  • PlateDesigner addresses the challenge of ad hoc randomization in microplate experiments.
  • It is freely available online at platedesigner.net.
  • The tool enhances the reliability and reproducibility of biological assay data.