Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Social Scripts02:10

Social Scripts

10.3K
People tend to know what behavior is expected of them in specific, familiar settings. A script is a person’s knowledge about the sequence of events expected in a specific setting (Schank & Abelson, 1977). Essentially, scripts are a particular kind of schema, one containing default values for the features within an event. In the restaurant example, the script's features include the props (e.g., tables, menu, food, and money), the roles to be played (e.g., customer and waiter),...
10.3K
Social Proof00:52

Social Proof

32.4K
Social proof is a form of persuasion based on comparison and conformity. People compare their behavior and actions to what others are doing and will change to conform to do what their peers do.
32.4K
Social Traps01:41

Social Traps

26.9K
Social traps are negative situations where people get caught in a direction or relationship that later proves to be unpleasant, with no easy way to back out of or avoid. The concept was orignally introduced by John Platt who applied psychology to Garrett Hardin's "Tragedy of the Commons", where in New England herd owners could let their cattle graze in the common ground. This situation seems like a good idea, but an individual could have an advantage. If they owned...
26.9K
Social Facilitation01:04

Social Facilitation

36.6K
Not all intergroup interactions lead to negative outcomes. Sometimes, being in a group situation can improve performance. Social facilitation occurs when an individual performs better when an audience is watching than when the individual performs the behavior alone. This typically occurs when people are performing a task for which they are skilled.
36.6K
Social Loafing01:37

Social Loafing

39.7K
Another way in which a group presence can affect performance is social loafing—the exertion of less effort by a person working together with a group. Social loafing occurs when our individual performance cannot be evaluated separately from the group. Thus, group performance declines on easy tasks (Karau & Williams, 1993). Essentially individual group members loaf and let other group members pick up the slack. Because each individual’s efforts cannot be evaluated,...
39.7K
Social Exchange Theory02:06

Social Exchange Theory

40.8K
We have discussed why we form relationships, what attracts us to others, and different types of love. But what determines whether we are satisfied with and stay in a relationship? One theory that provides an explanation is social exchange theory. According to social exchange theory, we act as naïve economists in keeping a tally of the ratio of costs and benefits of forming and maintaining a relationship with others (Rusbult & Van Lange, 2003).
40.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multimodal antibacterial agents based on photodynamic therapy and photothermal therapy: principles, design strategies and applications.

Chemical Society reviews·2026
Same author

Regional versus general anesthesia for femur and hip fracture surgery: A meta-analysis of postoperative outcomes and complications.

The Journal of international medical research·2026
Same author

Does postoperative exercise after hip arthroplasty improve strength and function? A systematic review and meta-analysis.

BMC musculoskeletal disorders·2026
Same author

rRGD3<sup>mu</sup>, a Triple-RGD Recombinant Peptide, Suppresses Malignant Phenotypes in Nasopharyngeal Carcinoma-Associated Models Through the Modulation of ITGB1-Associated FAK/AKT Signaling.

International journal of molecular sciences·2026
Same author

Rhein antagonizes glucocorticoid receptor signaling to activate SIRT1-dependent thermogenesis in brown adipose tissue and ameliorate obesity.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same author

Advances in BODIPY Derivatives for Antibacterial Phototherapy.

Angewandte Chemie (International ed. in English)·2026

Related Experiment Video

Updated: Feb 4, 2026

The Social Dimension of Stress: Experimental Manipulations of Social Support and Social Identity in the Trier Social Stress Test
11:13

The Social Dimension of Stress: Experimental Manipulations of Social Support and Social Identity in the Trier Social Stress Test

Published on: November 19, 2015

14.5K

Social Isolation Induces Rac1-Dependent Forgetting of Social Memory.

Yunlong Liu1, Li Lv1, Lianzhang Wang1

  • 1Tsinghua-Peking Center for Life Sciences, IDG/McGovern Institute for Brain Research, MOE Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Cell Reports
|October 11, 2018
PubMed
Summary

Social isolation accelerates forgetting of social recognition memory (SRM) in mice, not impairing memory formation. This is due to increased Rac1 activity in the hippocampus, which can be reversed by resocialization.

Keywords:
Rac1forgettingresocializationsocial isolationsocial recognition memory

More Related Videos

Assessment of Social Transmission of Food Preferences Behaviors
04:56

Assessment of Social Transmission of Food Preferences Behaviors

Published on: January 25, 2018

8.6K
Assessment of Social Interaction Behaviors
06:41

Assessment of Social Interaction Behaviors

Published on: February 25, 2011

95.3K

Related Experiment Videos

Last Updated: Feb 4, 2026

The Social Dimension of Stress: Experimental Manipulations of Social Support and Social Identity in the Trier Social Stress Test
11:13

The Social Dimension of Stress: Experimental Manipulations of Social Support and Social Identity in the Trier Social Stress Test

Published on: November 19, 2015

14.5K
Assessment of Social Transmission of Food Preferences Behaviors
04:56

Assessment of Social Transmission of Food Preferences Behaviors

Published on: January 25, 2018

8.6K
Assessment of Social Interaction Behaviors
06:41

Assessment of Social Interaction Behaviors

Published on: February 25, 2011

95.3K

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Behavioral Biology

Background:

  • Social isolation (SI) negatively impacts cognitive functions in humans and animals.
  • Acute SI in adult mice leads to impaired social recognition memory (SRM).
  • Previous research focused on memory consolidation deficits, not forgetting.

Purpose of the Study:

  • To investigate the role of enhanced forgetting in social isolation-induced SRM impairment.
  • To identify the molecular mechanisms underlying accelerated SRM decay.
  • To explore potential interventions for reversing social memory deficits.

Main Methods:

  • Adult mice were subjected to social isolation or group housing.
  • Adeno-associated virus (AAV)-based genetic manipulation was used to modulate Rac1 activity in the hippocampus.
  • Social recognition memory (SRM) was assessed using behavioral paradigms.
  • Long-term potentiation (LTP) decay was measured in hippocampal brain slices.
  • Resocialization protocols were implemented to assess reversal of memory deficits.

Main Results:

  • Social isolation accelerated SRM decay without affecting memory formation.
  • Elevated Rac1 activity in the hippocampus was identified as the cause of enhanced forgetting.
  • Inhibition of Rac1 activity in isolated mice prevented SRM forgetting.
  • Activation of Rac1 in group-housed mice accelerated forgetting.
  • Resocialization reversed isolation-induced forgetting, correlating with Rac1 activity suppression.
  • Accelerated LTP decay in isolated mice was rescued by inhibiting Rac1 activity.

Conclusions:

  • Social memory deficits in isolated mice are mediated by enhanced Rac1-dependent forgetting.
  • Rac1 activity in the hippocampus is a key regulator of social memory decay.
  • Targeting Rac1 activity offers a potential therapeutic strategy for social isolation-induced cognitive impairments.