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The 10,000 Immunomes Project: Building a Resource for Human Immunology
Kelly A Zalocusky1, Matthew J Kan1, Zicheng Hu1
1Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94158, USA.
Cell Reports
|October 11, 2018
Summary
The 10,000 Immunomes Project (10KIP) establishes a diverse human immunology reference. This framework analyzes immune variations across demographics and conditions, providing a baseline for future research.
Area of Science:
- Immunology
- Human biology
- Computational biology
Background:
- The immune system's role extends beyond infection to areas like tumorigenesis, metabolism, and neurobiology.
- A significant barrier to understanding human immunology is the lack of reproducible immune assays in large, diverse healthy cohorts.
Purpose of the Study:
- To establish a framework for a diverse human immunology reference dataset.
- To enable robust comparisons of immunological data across a large cohort.
- To characterize variations in immune markers by demographic factors and physiological states.
Main Methods:
- Utilized the ImmPort database, a public resource for immunology data.
- Developed the 10,000 Immunomes Project (10KIP) framework.
- Analyzed serum cytokines and leukocytes, correlating with age, race, sex, and pregnancy.
Main Results:
- Described variations in serum cytokines and leukocytes based on age, race, and sex.
- Defined a baseline human cell-cytokine network.
- Characterized immunological changes associated with pregnancy.
Conclusions:
- The 10KIP provides a valuable, publicly accessible resource for human immunology research.
- The characterized variations offer insights into immune system heterogeneity.
- This framework supports further investigation into the immune system's multifaceted roles.
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