Related Experiment Video
Updated: Feb 4, 2026
05:54
A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring
Published on: November 29, 2024
2.2K
Key Cell Functions are Modulated by Compression in an Animal Model of Hypertrophic Scar.
Abdulnaser Alkhalil1, Bonnie C Carney1, Taryn E Travis2
1Firefighters' Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, DC.
Wounds : a Compendium of Clinical Research and Practice
|October 11, 2018
Summary
Compression therapy significantly alters gene expression in hypertrophic scars (HTS), impacting biological functions and improving scar appearance. This study used an automated pressure delivery system (APDS) for controlled HTS treatment.
Area of Science:
- Biomedical Engineering
- Dermatology
- Molecular Biology
Background:
- Hypertrophic scar (HTS) treatment efficacy is limited by poor controls and unclear mechanisms.
- Compression therapy's value is often underestimated in HTS management.
Purpose of the Study:
- To investigate the genome-wide effects of compression on scar tissue.
- To assess transcriptional changes under controlled compression conditions.
Main Methods:
- Utilized an automated pressure delivery system (APDS) to apply 30 mm Hg pressure to swine HTS models.
- Collected scar specimens at early, mid, and late phases relative to compression initiation.
- Performed genome-wide transcriptome analysis on scar tissues.
Main Results:
- Transcriptome profiles diverged between compression and sham groups by the mid-phase.
- Most transcriptional changes persisted from mid to late phases.
- Compression altered pathways including calcium signaling and cholesterol synthesis.
Conclusions:
- Compression effectively modulates gene transcription in hypertrophic scars.
- These transcriptional changes correlate with improved scar characteristics.
Related Concept Videos
02:35Key Elements for Plant Nutrition
24.3K
Like all living organisms, plants require organic and inorganic nutrients to survive, reproduce, grow and maintain homeostasis. To identify nutrients that are essential for plant functioning, researchers have leveraged a technique called hydroponics. In hydroponic culture systems, plants are grown—without soil—in water-based solutions containing nutrients. At least 17 nutrients have been identified as essential elements required by plants. Plants acquire these elements from the...
24.3K
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
490
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
490
01:19Key Techniques in Microbiology
2.4K
Aseptic techniques prevent contamination, ensure experimental accuracy, and protect researchers and microbial cultures. These techniques are essential in clinical, industrial, and research settings where sterility is required.Maintaining Sterility in Laboratory PracticesScientists maintain sterility by sterilizing tools with heat or chemicals, disinfecting work surfaces, and handling cultures in controlled environments. Working near an open flame or within a laminar flow hood reduces the risk...
2.4K
01:30Animal and Plant Cell Structure
48.3K
Animal and plant cells not only differ in their structure, function, and mode of nutrition but also in how they reproduce, specialize, and organize into complex structures.
Cell Division
Though both plant and animal cells divide by mitosis (for non-gametic cells) and meiosis (for gametic cells), they differ in the specifics of this process. Unlike animal cells, plant cells lack centrosomes — an organelle responsible for organizing the spindle fibers and segregating the chromosomes during...
Cell Division
Though both plant and animal cells divide by mitosis (for non-gametic cells) and meiosis (for gametic cells), they differ in the specifics of this process. Unlike animal cells, plant cells lack centrosomes — an organelle responsible for organizing the spindle fibers and segregating the chromosomes during...
48.3K
02:59Animal Mitochondrial Genetics
9.2K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.2K
01:23Behavior of Concrete Under Compressive Load
630
Concrete exhibits specific behaviors under different compressive loads. Understanding this is crucial for understanding its structural integrity. When concrete undergoes uniaxial compression, it tends to develop cracks that run parallel to the direction of the force. These parallel cracks stem from localized tensile stresses that occur perpendicular to the compression direction. Additionally, angled cracks may appear due to the formation of shear planes.
As the concrete specimen fractures under...
As the concrete specimen fractures under...
630