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Updated: Feb 4, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
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Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

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Elevated Serum Exosomal miR-125b Level as a Potential Marker for Poor Prognosis in Intermediate-Risk Acute Myeloid

Lijun Jiang, Taoran Deng, Di Wang

    Acta Haematologica
    |October 11, 2018
    PubMed
    Abstract

    Insights

    Elevated exosomal miR-125b levels in adult acute myeloid leukemia patients indicate a higher risk of relapse and death. This finding suggests miR-125b may serve as a crucial prognostic biomarker.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Biomarkers

    Background:

    • The prognostic value of miR-125b in intermediate-risk acute myeloid leukemia (AML) is not well-established.
    • Exosomal microRNAs are increasingly recognized for their role in cancer progression and as potential biomarkers.

    Purpose of the Study:

    • To investigate the prognostic significance of exosomal miR-125b levels in adult patients with intermediate-risk AML.
    • To determine the association between elevated exosomal miR-125b and patient outcomes, including relapse and overall survival.

    Main Methods:

    • Quantitative real-time polymerase chain reaction (qRT-PCR) was used to measure exosomal miR-125b levels in 154 intermediate-risk AML patients.
    • Patients were stratified into high and low miR-125b groups and followed for 1-24 months for relapse and death.
    • Multivariate Cox regression and Kaplan-Meier analyses were employed to assess prognostic impact.

    Main Results:

    • A high exosomal miR-125b level was significantly associated with an increased risk of relapse (HR 2.84) and overall death (HR 2.69) within 2 years.
    • Kaplan-Meier analysis confirmed that high miR-125b levels correlated with higher cumulative relapse and overall death rates (p < 0.001).

    Conclusions:

    • Circulating exosomal miR-125b concentration may serve as an independent prognostic indicator in intermediate-risk AML.
    • Elevated exosomal miR-125b levels are indicative of a poorer prognosis, highlighting its potential as a predictive biomarker for treatment stratification.
    Keywords:
    Acute myeloid leukemiaExosomesMIRN125 microRNAOverall deathRecurrence

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