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Comparison between Hyper-CVAD and PETHEMA ALL-93 in Adult Acute Lymphoblastic Leukemia: A Single-Center Study

Nergiz Erkut1, Osman Akidan2, Derya Selim Batur3

  • 1Department of Hematology, School of Medicine, Karadeniz Technical University, Trabzon, Turkeydrnusta@hotmail.com.

Chemotherapy
|October 11, 2018
PubMed

Insights

This study compared two adult acute lymphoblastic leukemia (ALL) chemotherapy regimens, Hyper-CVAD and PETHEMA ALL-93. While both showed similar survival outcomes, Hyper-CVAD was better tolerated with fewer toxicities.

Area of Science:

  • Hematology
  • Oncology
  • Clinical Trials

Background:

  • Adult acute lymphoblastic leukemia (ALL) has lower cure rates compared to pediatric ALL.
  • Current treatments include Hyper-CVAD and PETHEMA ALL-93, but direct comparisons are lacking.

Purpose of the Study:

  • To compare the efficacy and safety of Hyper-CVAD and PETHEMA ALL-93 regimens in adult ALL patients.
  • To evaluate complete response, overall survival, and disease-free survival rates.
  • To assess treatment-related toxicities between the two regimens.

Main Methods:

  • Retrospective single-center study of 51 adult ALL patients.
  • Patients received either Hyper-CVAD (38 patients) or PETHEMA ALL-93 (13 patients).
  • Data collected on treatment response, survival, and adverse events.

Main Results:

  • Complete response rates were 90% for Hyper-CVAD and 100% for PETHEMA ALL-93.
  • Median overall survival and disease-free survival were comparable between regimens (approx. 18 months OS, 13 months DFS).
  • PETHEMA ALL-93 was associated with higher rates of hepatotoxicity, hypofibrinogenemia, aspergillus infection, and skin rash compared to Hyper-CVAD.

Conclusions:

  • Hyper-CVAD and PETHEMA ALL-93 demonstrate similar survival outcomes in adult ALL.
  • Hyper-CVAD exhibited a better safety profile with fewer adverse events.
  • Patient age and comorbidities are crucial factors in selecting the optimal chemotherapy regimen.
Abstract

Keywords:
Acute lymphoblastic leukemiaHyper-CVADPETHEMA ALL-93Side effectsSurvival

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