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Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
MiR-1204 promotes ovarian squamous cell carcinoma growth by increasing glucose uptake
Jia Xu1, XiaoLi Gu1, Xiaozhuo Yang2
1Department of Obstetrics and Gynecology, The second affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, PR China.
Abstract:
MiR-1204 has been recently identified as an oncogenic miRNA in breast cancer. Our study aims to investigate the role of miR-1204 in ovarian squamous cell carcinoma. Expression of miR-1204 and glucose transporter 1 in ovarian biopsies and plasma of both OC patients and healthy controls was detected by qRT-PCR. Correlations between patients' clinicopathological data were analyzed by Chi-square test. MiR-1204 overexpression OC cell lines were established. Expression of GLUT-1 protein was detected by western blot. Glucose uptake was measured by glucose uptake assay. Cell proliferation was detected by CCK-8 assay. We found that miR-1204 expression was significantly correlated with tumor size. Expression levels of miR-1204 and GLUT-1 were significantly high in OC patients. Expression levels of miR-1204 were positively correlated with expression levels of GLUT-1 in OC patients. MiR-1204 overexpression significantly promoted GLUT-1 expression, glucose uptake and cell proliferation. MiR-1204 may promote ovarian squamous cell carcinoma growth by increasing glucose uptake.
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