Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

"Peripheral" benzodiazepine binding sites in the Maudsley reactive rat: selective decrease confined to peripheral

R C Drugan, A S Basile, J N Crawley

    Brain Research Bulletin
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Spaced training improves learning in Ts65Dn and Ube3a mouse models of intellectual disabilities.

    Translational psychiatry·2019
    Same author

    Touchscreen learning deficits in Ube3a, Ts65Dn and Mecp2 mouse models of neurodevelopmental disorders with intellectual disabilities.

    Genes, brain, and behavior·2017
    Same author

    Neuregulin-2 ablation results in dopamine dysregulation and severe behavioral phenotypes relevant to psychiatric disorders.

    Molecular psychiatry·2017
    Same author

    Behavioral phenotypes of genetic mouse models of autism.

    Genes, brain, and behavior·2015
    Same author

    GABAB Receptor Agonist R-Baclofen Reverses Social Deficits and Reduces Repetitive Behavior in Two Mouse Models of Autism.

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2015
    Same author

    3D visualization of the regional differences.

    Molecular psychiatry·2015
    Same journal

    Transcranial direct current stimulation alleviates depression-like behaviors by activating the ACC-ZI neural circuit.

    Brain research bulletin·2026
    Same journal

    Regional Structural-Functional Coupling in Generalized Anxiety Disorder and Association with Neurotransmitter and Gene Signature.

    Brain research bulletin·2026
    Same journal

    Hydroxyurea Promotes Brain Development in Children with Sickle Cell Anemia.

    Brain research bulletin·2026
    Same journal

    Are T1-weighted and T2-weighted volumetric pipelines interchangeable methodologies for investigating amyotrophic lateral sclerosis pathology in vivo?

    Brain research bulletin·2026
    Same journal

    Global Research Trends and Mechanistic Insights of Sirtuins in Alzheimer's Disease: A Bibliometric and Translational Review.

    Brain research bulletin·2026
    Same journal

    N6-methyladenosine demethylase ALKBH5 mediates remote ischemic postconditioning in cerebral ischemia-reperfusion injury by regulating KLF4.

    Brain research bulletin·2026
    See all related articles

    Peripheral benzodiazepine binding sites (PBS) are reduced in the heart and kidney of fear-prone rats. This finding in Maudsley reactive rats suggests a link between PBS levels and anxiety-related behaviors.

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Behavioral Science

    Background:

    • Peripheral benzodiazepine binding sites (PBS) are implicated in various physiological processes.
    • Differences in PBS density have been observed in animal models of stress and anxiety.

    Purpose of the Study:

    • To investigate the density of PBS in the central nervous system (CNS) and peripheral tissues of Maudsley reactive (MR) and Maudsley non-reactive (MNR) rats.
    • To determine if fearfulness, as modeled by the MR rat strain, correlates with altered PBS levels.

    Main Methods:

    • Utilized the specific PBS ligand [3H]Ro 5-4864 for binding assays.
    • Compared PBS density in various CNS regions (cortex, hippocampus, hypothalamus) and peripheral tissues (heart, kidney, lung, adrenal) between MR and MNR rats.

    Related Experiment Videos

    Main Results:

    • A statistically significant reduction in PBS density was observed in the heart and kidney of MR rats compared to MNR rats.
    • No significant differences in PBS density were found in the studied CNS areas or other peripheral tissues (lung, adrenal).

    Conclusions:

    • Selective decrease in heart and kidney PBS density in MR rats suggests a link to their heightened fearfulness.
    • Findings may relate to previous studies showing reduced PBS in rats exposed to uncontrollable shock.
    • Peripheral benzodiazepine binding sites in the heart and kidney may be sensitive to fear and anxiety states.