Predictive value of pediatric respiratory-induced diaphragm motion quantified using pre-treatment 4DCT and CBCTs

In adults, a single pre-treatment four-dimensional CT (4D-CT) acquisition is often used to account for respiratory-induced target motion during radiotherapy. However, studies have indicated that a 4D-CT is not always representative for respiratory motion. Our aim was to investigate whether respiratory-induced diaphragm motion in children on a single pre-treatment 4DCT can accurately predict respiratory-induced diaphragm motion as observed on cone beam CTs (CBCTs).

Twelve patients (mean age 14.5 yrs.; range 8.6-17.9 yrs) were retrospectively included based on visibility of the diaphragm on abdominal or thoracic imaging data acquired during free breathing. A 4DCT for planning purposes and daily/weekly CBCTs (total 125; range 4-29 per patient) acquired prior to dose delivery were available. The amplitude, corresponding to the difference in position of the diaphragm in cranial-caudal direction in end-inspiration and end-expiration phases, was extracted from the 4DCT (A_4DCT). The amplitude in CBCTs (A_CBCT) was defined as displacement between averaged in- and expiration diaphragm positions on corresponding projection images, and the distribution of A_CBCT was compared to A_4DCT (one-sample t-test, significance level p < 0.05).

Over all patients, the mean A_4DCT was 10.4 mm and the mean A_CBCT 11.6 mm. For 9/12 patients, A_4DCT differed significantly (p < 0.05) from A_CBCT. Differences > 3 mm were found in 69/125 CBCTs (55%), with A_4DCT mostly underestimating A_CBCT. For 7/12 patients, diaphragm positions differed significantly from the baseline position.

Respiratory-induced diaphragm motion determined on 4DCT does not accurately predict the daily respiratory-induced diaphragm motion observed on CBCTs, as the amplitude and baseline position differed statistically significantly in the majority of patients. Regular monitoring of respiratory motion during the treatment course using CBCTs could yield a higher accuracy when a daily adaptation to the actual breathing amplitude takes place.