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Updated: Feb 4, 2026

Cochlear Implantation in the Guinea Pig
Published on: June 15, 2018
Using Hysterectomy Rederivation to Produce Guinea Pigs (Cavia porcellus) Free of Guinea Pig Cytomegalovirus
Kathleen R Pritchett Corning1, Guy B Mulder2, Kenneth S Henderson2
1Charles River Laboratories, Wilmington, Massachusetts, USA; Office of Animal Resources, Faculty of Arts and Sciences, Harvard University, Cambridge, Massachusetts, USA. pritchettcorning@fas.harvard.edu.
Abstract:
Due to similarities in placentation, guinea pigs can be used as models of human cytomegalovirus infection, but they must be free of guinea pig cytomegalovirus. Many commercial guinea pig colonies are enzootically infected with guinea pig cytomegalovirus, which can be transmitted vertically as well as horizontally through saliva, vaginal secretions, and milk. These characteristics make its eradication in a commercial setting challenging. Because embryo transfer technology in guinea pigs is in its infancy, it is not generally a viable option for obtaining animals free of guinea pig cytomegalovirus. However, a combination of hysterectomy rederivation and testing by PCR assay and serology of both dams and offspring from an enzootically infected colony produced offspring free of guinea pig cytomegalovirus.
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