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Related Concept Videos

Schemas01:42

Schemas

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A schema is a mental construct consisting of a cluster or collection of related concepts (Bartlett, 1932). There are many different types of schemata, and they all have one thing in common: schemata are a method of organizing information that allows the brain to work more efficiently. When a schema is activated, the brain makes immediate assumptions about the person or object being observed.
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Related Experiment Video

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Zebrafish Model of Neuroblastoma Metastasis
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Zebrafish Model of Neuroblastoma Metastasis

Published on: March 14, 2021

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Update on neuroblastoma.

Erika A Newman1, Shahab Abdessalam2, Jennifer H Aldrink3

  • 1C.S Mott Children's Hospital, The University of Michigan Medicine, Ann Arbor, MI.

Journal of Pediatric Surgery
|October 12, 2018
PubMed
Summary
This summary is machine-generated.

Neuroblastoma, a common childhood cancer from neural crest stem cells, shows variable outcomes. Advances in understanding tumor biology and genetics are improving neuroblastoma staging, risk stratification, and treatment.

Keywords:
CancerNeuroblastomaOncologySolid tumorSurgeryTreatment

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Area of Science:

  • Pediatric Oncology
  • Cancer Biology
  • Genetics

Background:

  • Neuroblastoma is a prevalent embryonic cancer originating from neural crest stem cells.
  • It is the most common infant malignancy and extracranial solid tumor in children.
  • Clinical presentation varies widely, from spontaneous regression in infants to aggressive disease in older children.

Purpose of the Study:

  • To review current advancements in neuroblastoma staging.
  • To discuss progress in risk stratification for neuroblastoma patients.
  • To highlight evolving treatment strategies informed by tumor biology and genetic insights.

Main Methods:

  • Literature review of recent studies on neuroblastoma.
  • Analysis of data on tumor biology and genetic characterization.
  • Synthesis of information on staging, risk, and treatment.

Main Results:

  • Tumor biology and genetic profiling are crucial for understanding neuroblastoma heterogeneity.
  • Current staging and risk stratification systems are being refined.
  • New therapeutic approaches are emerging based on molecular understanding.

Conclusions:

  • Understanding neuroblastoma's diverse biology is key to personalized treatment.
  • Continued research in genetics and tumor characteristics will further refine patient management.
  • Improved staging and risk stratification enhance therapeutic efficacy and patient outcomes.