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Updated: Feb 4, 2026

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Visualizing Membrane Ruffle Formation using Scanning Electron Microscopy
Published on: May 27, 2021
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A tent pole twist on membrane ruffles
Reuben V Philip1, Rene E Harrison1
1University of Toronto, Toronto, Canada.
The Journal of Cell Biology
|October 12, 2018
Abstract:
Macropinocytosis or "cell drinking" involves the elaboration of membrane ruffles that enclose and internalize extracellular fluids. Using lattice light sheet microscopy, Condon et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201804137) reveal the presence of parallel membrane protrusions termed "tent poles" that flank and direct membrane ruffle formation.
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