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Related Concept Videos

Next-generation Sequencing03:00

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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
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Implementation is the execution of the nursing care plan developed during the planning phase.
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Uncertainty in Measurement: Accuracy and Precision03:37

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Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. 
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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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Understanding the formal definition of a limit is essential for precise mathematical analysis. This concept allows us to rigorously determine how a function behaves near a particular point without relying on ambiguous notions such as "getting close." The ε-δ definition plays a foundational role in calculus, ensuring analytical clarity and logical consistency in limit evaluation.The formal definition states that the limit of a function f(x) as x approaches a is L, written asif for...
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Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research
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[Implementing next-generation sequencing for precision hematology/oncology].

Takahiro Maeda1

  • 1Center for Cellular and Molecular Medicine, Kyushu University Hospital.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|October 12, 2018
PubMed
Summary
This summary is machine-generated.

Precision medicine tailors treatments using individual data. Cancer genome sequencing offers significant benefits in hematology/oncology, despite technical and ethical challenges.

Keywords:
Next-generation sequencingPrecision medicine

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Area of Science:

  • Genomics
  • Oncology
  • Precision Medicine

Background:

  • The Precision Medicine Initiative, launched in 2015, aims to personalize medical treatments.
  • Precision medicine utilizes patient lifestyle, genetic, and molecular data for tailored therapies.
  • Genomics-based oncology is the most clinically advanced application of precision medicine.

Purpose of the Study:

  • To discuss the advantages of cancer genome sequencing in hematology/oncology.
  • To highlight the technical and sociomedical challenges associated with its implementation.

Main Methods:

  • Review of current applications of cancer genome sequencing in hematology/oncology.
  • Analysis of technical aspects, including sequencing technologies and data analysis.
  • Examination of sociomedical challenges, such as cost, accessibility, and ethical considerations.

Main Results:

  • Cancer genome sequencing provides valuable insights for personalized cancer treatment strategies.
  • Significant advancements in understanding hematologic malignancies and solid tumors through genomic analysis.
  • Identified technical hurdles in data interpretation and clinical integration.
  • Recognized ethical and societal implications impacting widespread adoption.

Conclusions:

  • Cancer genome sequencing is a powerful tool in precision oncology, particularly in hematology.
  • Addressing technical and sociomedical challenges is crucial for realizing the full potential of genomic medicine.