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Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma
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[Methods and clinical values for minimal residual disease detection in patients with multiple myeloma]

Hiroyuki Takamatsu1

  • 1Department of Hematology/Respiratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|October 12, 2018
PubMed

Insights

Complete response rates in multiple myeloma are rising with new treatments. Minimal residual disease assessment is crucial for accurate prognoses and patient stratification.

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Complete response (CR) rates in multiple myeloma (MM) are increasing due to novel agents and combination therapies.
  • High CR rates, reaching 70% with novel agents and autologous stem-cell transplantation, necessitate refined prognostic tools.
  • Minimal residual disease (MRD) assessment is vital for stratifying CR patients and improving prognoses.

Purpose of the Study:

  • To review recent advancements in MRD detection methods for multiple myeloma.
  • To summarize the prognostic significance of MRD assessment in multiple myeloma patients.
  • To provide an overview of current MRD detection technologies and their clinical utility.

Main Methods:

  • Multiparameter flow cytometry (MFC)
  • Allele-specific oligonucleotide real-time quantitative PCR (ASO-qPCR)
  • Droplet digital PCR (ddPCR)
  • Next-generation sequencing (NGS)

Main Results:

  • Multiple myeloma treatment landscape evolving with novel agents.
  • High CR rates achieved with combination therapies and ASCT.
  • MRD assessment is critical for prognosis and patient management.

Conclusions:

  • MRD assessment is essential for accurate prognoses in multiple myeloma.
  • Various sensitive techniques are available for MRD detection.
  • Further research into MRD's role in MM management is warranted.
Keywords:
Allele-specific oligonucleotide-polymerase chain reactionMinimal residual diseaseMultiparameter flow cytometryNext-generation sequencing

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