[Hematopoietic stem cell transplantation in the era of new molecular-targeted therapies]
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Updated: Feb 4, 2026

Isolation and Transplantation of Hematopoietic Stem Cells HSCs
Published on: February 25, 2007
1Department of Hematology, Oncology & Cardiovascular Medicine, Kyushu University Hospital.
Abstract:
Recent advances in the field of molecular-targeted therapy have revolutionized the treatment of hematological malignancies. Consequentially, the role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) has dramatically changed. However, allo-HSCT remains vital in the treatment of hematological malignancies because cure is rarely achieved by targeted therapy only. In the new era of molecular-targeted treatment, its incorporation into allo-HSCT is key to achieving therapeutic success. In particular, the understanding of the immune impact of molecular-targeted therapy on graft-versus-host-disease and graft-versus-leukemia is essential to improve the outcome of allo-HSCT.
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