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Assessment of Quality of Life among Children with End-Stage Renal Disease: A Cross-Sectional Study
Arwa M El Shafei1, Ibrahim Soliman Hegazy1, Fatina Ibrahim Fadel2
1Department of Public Health and Community Medicine, Faculty of Medicine, Cairo University, Giza, Egypt.
Insights
Children with end-stage renal disease (ESRD) experience significantly lower quality of life compared to healthy peers. Treatment modalities for ESRD negatively impact all life quality aspects, necessitating integrated assessment and management.
Area of Science:
- Pediatric Nephrology
- Health Outcomes Research
- Quality of Life Studies
Background:
- Health-related quality of life (HRQoL) is a crucial metric for evaluating healthcare interventions and disease burden.
- Assessing HRQoL provides insights into patient well-being beyond clinical outcomes.
Purpose of the Study:
- To evaluate the quality of life in children diagnosed with end-stage renal disease (ESRD).
- To compare the HRQoL of children with ESRD undergoing hemodialysis or renal transplantation against healthy controls.
Main Methods:
- A cross-sectional study was conducted involving 55 children with ESRD and 86 healthy controls.
- The PedsQL™ Inventory (versions 4 and 3 for ESRD) was utilized for parent/child reports on quality of life.
Main Results:
- Children with ESRD reported significantly lower overall quality of life (mean score 58.4) compared to controls (mean score 86.8).
- All domains of quality of life were adversely affected in children with ESRD.
- The renal transplantation group showed a moderate positive correlation between child and parent quality of life scores.
Conclusions:
- End-stage renal disease and its treatments substantially impair all aspects of quality of life in children.
- Integrating quality of life assessment and management into clinical practice for pediatric ESRD patients is highly recommended.
Background:
Measuring health-related quality of life is considered an important outcome indicator in evaluating health-care interventions and treatments and in understanding the burden of diseases.
Objectives:
This study aimed at assessing quality of life among children with end-stage renal disease, either undergoing hemodialysis or had renal transplantation therapy and comparing it with healthy controls.
Methods:
A cross-sectional study was conducted between December 2016 and May 2017 in Abo El-Reesh Pediatric Hospital using parent/child reports of generic module for QoL assessment: PedsQLTM Inventory version 4 for both cases and controls. Disease-specific module: PedsQLTM ESRD version 3 was used for ESRD cases. 55 ESRD cases and 86 controls were enrolled in the study.
Results:
Statistically significant difference between ESRD cases and controls regarding all aspects of QoL was found; total QoL mean score was 58.4 ± 15.3 and 86.8 ± 10 among cases and controls, respectively. All individual QoL domains were significantly worse in ESRD cases. Transplantation group had better Spearman's correlation between child and parents' scores which showed significant positive moderate correlation.
Conclusions:
ESRD and its treatment modalities are affecting negatively all aspects of quality of life; incorporating QoL assessment and management is highly recommended.
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