Assessment of Quality of Life among Children with End-Stage Renal Disease: A Cross-Sectional Study

Arwa M El Shafei1, Ibrahim Soliman Hegazy1, Fatina Ibrahim Fadel2

  • 1Department of Public Health and Community Medicine, Faculty of Medicine, Cairo University, Giza, Egypt.

Insights

Children with end-stage renal disease (ESRD) experience significantly lower quality of life compared to healthy peers. Treatment modalities for ESRD negatively impact all life quality aspects, necessitating integrated assessment and management.

Area of Science:

  • Pediatric Nephrology
  • Health Outcomes Research
  • Quality of Life Studies

Background:

  • Health-related quality of life (HRQoL) is a crucial metric for evaluating healthcare interventions and disease burden.
  • Assessing HRQoL provides insights into patient well-being beyond clinical outcomes.

Purpose of the Study:

  • To evaluate the quality of life in children diagnosed with end-stage renal disease (ESRD).
  • To compare the HRQoL of children with ESRD undergoing hemodialysis or renal transplantation against healthy controls.

Main Methods:

  • A cross-sectional study was conducted involving 55 children with ESRD and 86 healthy controls.
  • The PedsQL™ Inventory (versions 4 and 3 for ESRD) was utilized for parent/child reports on quality of life.

Main Results:

  • Children with ESRD reported significantly lower overall quality of life (mean score 58.4) compared to controls (mean score 86.8).
  • All domains of quality of life were adversely affected in children with ESRD.
  • The renal transplantation group showed a moderate positive correlation between child and parent quality of life scores.

Conclusions:

  • End-stage renal disease and its treatments substantially impair all aspects of quality of life in children.
  • Integrating quality of life assessment and management into clinical practice for pediatric ESRD patients is highly recommended.
Abstract

Related Concept Videos

Cross-Sectional Research01:50

Cross-Sectional Research

In cross-sectional research, a researcher compares multiple segments of the population at the same time. If they were interested in people's dietary habits, the researcher might directly compare different groups of people by age. Instead of following a group of people for 20 years to see how their dietary habits changed from decade to decade, the researcher would study a group of 20-year-old individuals and compare them to a group of 30-year-old individuals and a group of 40-year-old...
12.5K
Finding Volume Using Cross-Sectional Area01:24

Finding Volume Using Cross-Sectional Area

For solids whose cross-sectional areas vary in a predictable way, volume can be determined by integrating these areas along an axis perpendicular to the slices. This approach is particularly useful for polyhedral solids, where classical geometric formulas may not be immediately applicable. A tetrahedron provides a clear example of how cross-sectional integration can be applied to a three-dimensional object with continuously changing geometry.Consider a tetrahedron with height h and a base that...
68
Profile Leveling and Cross Sections01:26

Profile Leveling and Cross Sections

Profile leveling and cross-sections are surveying methods used to determine and document terrain elevations for infrastructure projects such as highways, railroads, canals, and pipelines. These methods provide data for earthwork planning and alignment of proposed routes.  Profile leveling involves measuring elevations along a fixed line to create a vertical terrain profile. A surveyor sets up a leveling instrument at the benchmark (BM) and records a backsight (BS) to determine the...
1.6K
Spinal Cord: Cross-sectional Anatomy01:16

Spinal Cord: Cross-sectional Anatomy

The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
4.8K
Half-life of a Reaction02:42

Half-life of a Reaction

The half-life of a reaction (t1/2) is the time required for one-half of a given amount of reactant to be consumed. In each succeeding half-life, half of the remaining concentration of the reactant is consumed. For example, during the decomposition of hydrogen peroxide, during the first half-life (from 0.00 hours to 6.00 hours), the concentration of H2O2 decreases from 1.000 M to 0.500 M. During the second half-life (from 6.00 hours to 12.00 hours), the concentration decreases from 0.500 M to...
39.0K
Crossing Over01:34

Crossing Over

Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
172.0K