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Considerations in hiPSC-derived cartilage for articular cartilage repair

Akihiro Yamashita¹, Yoshihiro Tamamura¹, Miho Morioka¹

¹1Cell Induction and Regulation Field, Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.

Inflammation and Regeneration

|October 12, 2018

Abstract

Background:

A lack of cell or tissue sources hampers regenerative medicine for articular cartilage damage.

Main Text:

We review and discuss the possible use of pluripotent stem cells as a new source for future clinical use. Human induced pluripotent stem cells (hiPSCs) have several advantages over human embryonic stem cells (hESCs). Methods for the generation of chondrocytes and cartilage from hiPSCs have been developed. To reduce the cost of this regenerative medicine, allogeneic transplantation is preferable. hiPSC-derived cartilage shows low immunogenicity like native cartilage, because the cartilage is avascular and chondrocytes are segregated by the extracellular matrix. In addition, we consider our experience with the aberrant deposition of lipofuscin or melanin on cartilage during the chondrogenic differentiation of hiPSCs.

Short Conclusion:

Cartilage generated from allogeneic hiPSC-derived cartilage can be used to repair articular cartilage damage.

Keywords:

Articular cartilage Chondrocytes Induced pluripotent stem cells Regeneration Transplantation

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