Emerging Role of mTOR Signaling-Related miRNAs in Cardiovascular Diseases

Area of Science:

• Molecular Biology
• Cardiovascular Biology
• RNA Biology

Background:

• The mechanistic/mammalian target of rapamycin (mTOR) pathway regulates crucial cellular functions like growth, proliferation, and metabolism.
• MicroRNAs (miRs) are key posttranscriptional regulators of gene expression vital for cardiovascular homeostasis.
• The mTOR pathway is a central regulator in cardiovascular physiology and pathology, integrating various signals.

Purpose of the Study:

• To review the intricate mechanisms of interaction between the mTOR signaling pathway and miRs in cardiovascular pathophysiology.
• To summarize current knowledge on the interplay between mTOR and miRs in various heart diseases.
• To highlight advances in mTOR-targeted therapies and novel miR-based strategies for cardiovascular diseases.

Main Methods:

• Comprehensive literature review of studies investigating the mTOR-miR axis in cardiovascular diseases.
• Analysis of existing research on the roles of mTOR and miRs in myocardial infarction, hypertrophy, fibrosis, heart failure, arrhythmia, inflammation, and atherosclerosis.
• Evaluation of current clinical trials and emerging therapeutic strategies involving mTOR and miRs.

Main Results:

• Numerous studies demonstrate a significant interplay between miRNAs and the mTOR signaling circuit in diverse cardiovascular pathologies.
• The mTOR pathway and miRs are intricately linked, influencing processes such as cell growth, survival, and inflammation in the heart.
• Both mTOR and miRs represent promising therapeutic targets for managing cardiovascular diseases.

Conclusions:

• The interaction between the mTOR pathway and miRs is critical in cardiovascular health and disease.
• Understanding this crosstalk opens avenues for novel therapeutic strategies targeting both mTOR and miRs.
• Future research and clinical trials focusing on mTOR-miRs hold promise for treating cardiovascular diseases effectively.