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Role of Fatty Acid Binding Protein 4 (FABP4) in Kidney Disease

Min Shi1, Liang Ma1, Ping Fu1

  • 1Kidney Research Institute, Division of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China.

Current Medicinal Chemistry
|October 12, 2018
PubMed

Insights

Fatty acid binding protein 4 (FABP4) is linked to kidney disease progression and may predict kidney injuries. Inhibiting FABP4 shows protective effects, suggesting it as a potential therapeutic target for kidney diseases.

Area of Science:

  • Nephrology
  • Metabolic Disorders
  • Cardiovascular Health

Background:

  • Obesity and metabolic syndrome are independent risk factors for kidney disease.
  • Adipokines, including FABP4, play a role in linking metabolic disorders and kidney diseases.
  • FABP4, expressed in adipocytes and macrophages, is associated with renal dysfunction.

Purpose of the Study:

  • To review the role of FABP4 in kidney diseases.
  • To explore FABP4 as a predictor of renal injuries and cardiovascular events in ESRD patients.
  • To discuss FABP4 as a potential therapeutic target for kidney diseases.

Main Methods:

  • Review of clinical and experimental studies.
  • Analysis of FABP4 expression in kidney cells.
  • Evaluation of FABP4 inhibition effects on renal damage.

Main Results:

  • Circulating FABP4 is a potential predictor for renal injuries.
  • FABP4 expression in glomerular and tubular cells is involved in kidney disease pathogenesis.
  • Inhibition of FABP4 demonstrates protective effects against renal damage.

Conclusions:

  • FABP4 is implicated in the pathophysiology of kidney diseases.
  • FABP4 serves as a potential biomarker for renal and cardiovascular complications.
  • Targeting FABP4 may offer a novel therapeutic strategy for kidney diseases.
Keywords:
ESRDFABP4adipokinedrug targetkidney diseasepredictor.

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