Related Experiment Video

Updated: Feb 4, 2026

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
07:54

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting

Published on: March 25, 2019

8.7K

Targeting Membrane Receptors of Ovarian Cancer Cells for Therapy

Zhiquan Liang1, Ziwen Lu1, Yafei Zhang1

  • 1School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu 212013, China.

Current Cancer Drug Targets
|October 12, 2018
PubMed

Insights

Novel targeted therapeutics are needed for ovarian cancer due to late diagnosis and limited survival improvements. Receptor-mediated strategies targeting overexpressed membrane receptors show promise for treatment and imaging.

Area of Science:

  • Oncology
  • Gynecologic Oncology
  • Molecular Targeted Therapy

Background:

  • Ovarian cancer is a leading cause of death globally among gynecological malignancies.
  • Late-stage diagnosis and limited survival improvements over two decades highlight the need for new treatments.
  • Current ovarian cancer management lacks personalization despite recognized subtype heterogeneity.

Purpose of the Study:

  • To review novel targeted therapeutic strategies for ovarian cancer.
  • To explore the potential of targeting membrane receptors for treatment and imaging.
  • To discuss receptor-mediated delivery systems for ovarian cancer therapy.

Main Methods:

  • Literature review of targeted therapeutic strategies for ovarian cancer.
  • Analysis of membrane receptors overexpressed in ovarian cancer cells.
  • Evaluation of ligand-receptor binding for therapeutic delivery systems.

Main Results:

  • Several membrane receptors are identified as potential targets in ovarian cancer.
  • Receptor-mediated strategies offer potential for targeted drug delivery.
  • Multifunctional delivery systems based on ligand-receptor interactions are being developed.

Conclusions:

  • Targeting aberrantly overexpressed membrane receptors is a promising strategy for ovarian cancer.
  • Receptor-mediated therapies and delivery systems could improve treatment outcomes.
  • Further research into these targeted approaches is crucial for advancing ovarian cancer care and imaging.
Keywords:
Ovarian cancerPD-L1ligand-receptor bindingmembrane receptorspeptide vaccinationtargeted therapy.

More Related Videos

In vitro Enrichment of Ovarian Cancer Tumor-initiating Cells11:37

In vitro Enrichment of Ovarian Cancer Tumor-initiating Cells

Published on: February 18, 2015

14.2K
Enrichment for Chemoresistant Ovarian Cancer Stem Cells from Human Cell Lines11:50

Enrichment for Chemoresistant Ovarian Cancer Stem Cells from Human Cell Lines

Published on: September 10, 2014

13.9K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.9K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
Internal Receptors01:31

Internal Receptors

Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.7K
Receptor-mediated Endocytosis01:39

Receptor-mediated Endocytosis

Overview
110.9K
Types of Receptors: Cell Surface Receptors01:28

Types of Receptors: Cell Surface Receptors

Cell-surface receptors, also known as transmembrane receptors, are cell surface, membrane-anchored (integral) proteins that bind to external ligand molecules. This type of receptor spans the plasma membrane and performs signal transduction, converting an extracellular signal into an intracellular signal. Ligands that interact with cell-surface receptors do not have to enter the cell that they affect. Cell-surface receptors are also called cell-specific proteins or markers because they are...
27.4K
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K