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Updated: Feb 4, 2026

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
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Cannabidiol affects circadian clock core complex and its regulation in microglia cells

Geneviève Lafaye1,2, Christophe Desterke3, Laurent Marulaz1,2

  • 1Dpt Addictologie, AP-HP, GH Paris-Sud, Hôpital Paul Brousse, Villejuif, France.

Addiction Biology
|October 12, 2018
PubMed
Summary

Cannabidiol (CBD) disrupts circadian gene regulation in microglial cells, impacting sleep patterns. This cannabis component affects key genes like Arntl and Clock, unlike THC, aligning with therapeutic cannabis use for insomnia.

Keywords:
THCcannabidiolcircadian genesmicroglial cells

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