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Updated: Feb 4, 2026
The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
Published on: June 30, 2014
Sarcoidosis following alemtuzumab treatment for multiple sclerosis
Mark D Willis1, Ben Hope-Gill2, Patrick Flood-Page3
1Institute of Psychological Medicine and Clinical Neuroscience, Cardiff University and University Hospital of Wales, Cardiff, UK; Department of Neurology, University Hospital of Wales, Cardiff, UK.
Abstract:
Despite proven efficacy of alemtuzumab in multiple sclerosis (MS), approximately 50% of individuals will develop a new autoimmune disease following treatment. To date, these have largely been antibody mediated and organ specific (primarily affecting the thyroid gland). In a retrospective case series of 187 patients from two UK specialist centres (Cardiff and Cambridge) followed up for a median of 10 years, we report three (1.6%) cases of sarcoidosis following alemtuzumab treatment of MS. This report increases the spectrum of auto-inflammatory disease following alemtuzumab and should be considered by clinicians when using this therapeutic agent for MS.
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