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Updated: Feb 4, 2026
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
Acute sarcoidosis in a multiple sclerosis patient after alemtuzumab treatment
Jonas Graf1, Marius Ringelstein1, Klaudia Lepka1
1Department of Neurology, University Hospital Düsseldorf, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Background:
Understanding the long-term effect of alemtuzumab on the immune system of multiple sclerosis (MS) patients is crucial.
Objective:
To report a case of acute sarcoidosis (Löfgren's syndrome) in a relapsing-remitting MS patient, 1.5 years after the second course of alemtuzumab treatment.
Case Report:
Sarcoidosis was confirmed dermatohistologically, radiologically, and serologically. Analysis of the lymphocyte subpopulations showed a persistent effect of alemtuzumab treatment (CD4/CD8 ratio increased, absolute lymphocyte count of CD19-positive cells increased while CD3/4/8-positive cells were decreased).
Conclusion:
Our case highlights the profound effect of alemtuzumab on the immune system and its possible risk for autoimmune complications.
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