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The Fountain of Youth: It's All in Our Veins
Amaia Dominguez-Belloso1, Stefan Liebner1
1Institute of Neurology (Edinger Institute), University Hospital Frankfurt, Goethe University, Heinrich-Hoffmann-Straße 7, 60528 Frankfurt, Germany.
Neuron
|October 12, 2018
Abstract:
Cardiovascular dysfunction becomes recognized as a risk for dementia. In this issue of Neuron, Park et al. (2018) report the age-related, brain endothelial-specific upregulation of acid sphingomyelinase (ASM), leading to blood-brain barrier malfunction, neurodegeneration, and memory deficits that were mitigated by ASM inhibition in mice.