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Serum angiotensin-converting enzyme activity in psoriasis.
Dermatologica
|January 1, 1987
Summary
Serum angiotensin-converting enzyme (SACE) activity is not typically elevated in psoriasis patients. Normal SACE levels in psoriasis suggest that elevated activity may indicate coexisting sarcoidosis.
Area of Science:
- Biochemistry
- Dermatology
- Immunology
Background:
- Conflicting literature exists regarding elevated serum angiotensin-converting enzyme (SACE) activity in psoriasis.
- Psoriasis is a chronic inflammatory skin condition with complex underlying mechanisms.
Purpose of the Study:
- To investigate whether enhanced SACE activity is a characteristic finding in psoriasis.
- To determine the relationship between SACE levels, psoriasis, and carbohydrate metabolism abnormalities.
Main Methods:
- Serum SACE activity was measured in 27 patients with psoriasis.
- SACE levels were also assessed in 18 healthy controls and 30 patients with essential hypertension.
- Correlation with psoriasis severity and metabolic status was analyzed.
Main Results:
- Serum angiotensin-converting enzyme (SACE) levels were found to be normal in psoriatic patients.
- SACE levels did not correlate with the presence of carbohydrate metabolism abnormalities.
- No relationship was observed between SACE levels and the severity of psoriatic skin lesions.
Conclusions:
- Elevated SACE activity is not a typical biomarker for psoriasis.
- In psoriatic individuals, elevated SACE may suggest an undiagnosed systemic sarcoidosis.
- Further investigation is warranted to explore the link between psoriasis and sarcoidosis markers.