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Updated: Feb 4, 2026

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
Published on: December 16, 2022
Crossed cerebellar diaschisis in Creutzfeldt-Jakob disease evaluated through single photon emission computed
Kenya Nishioka1, Michimasa Suzuki2, Katsuya Satoh3
1Department of Neurology, Juntendo University School of Medicine, 3-1-1 Hongo, Bunkyo, Tokyo 113-8421, Japan.
Abstract:
Sporadic Creutzfeldt-Jakob disease (sCJD) is the most common form of human prion disease; it is characterized as a transmissible spongiform encephalopathy. Previously, only two case reports have discussed crossed cerebellar diaschisis (CCD) and sCJD. Herein, we detected CCD in five patients with sCJD and four patients with genetic CJD through SPECT. The combined data of the nine patients further supported CCD when analyzed by 3D-SSP. CCD can occur in several disorders, including, stroke, epilepsy, and encephalitis. Hence, CCD possibly could help in making earlier CJD diagnoses. Further studies with more patients are necessary to confirm the strong relationship here suggested between CJD and CCD.
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