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Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation

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Surfaceome nanoscale organization and extracellular interaction networks.

Damaris Bausch-Fluck¹, Emanuela Sara Milani¹, Bernd Wollscheid¹

¹Institute of Molecular Systems Biology & Department of Health Sciences and Technology, ETH Zürich, Zürich, Switzerland.

Current Opinion in Chemical Biology

|October 12, 2018

Summary

Understanding the surfaceome, the cell surface proteins, is crucial for developing effective drugs. This review explores surfaceome organization and interactions for better therapeutic strategies.

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Area of Science:

Biochemistry
Molecular Biology
Pharmacology

Background:

The 'one target-one drug' approach often fails in vivo due to complex biological systems.
Protein signaling networks are key to understanding and treating diseases.
The surfaceome, or cell surface proteins, acts as a crucial interface for cellular communication.

Purpose of the Study:

To review the current knowledge on the spatial organization and molecular interactions of the surfaceome.
To provide a perspective on technologies for studying the extracellular surfaceome interaction network.
To highlight the surfaceome's importance as a source for diagnostic and therapeutic agents.

Main Methods:

Literature review of current research on surfaceome organization and interactions.
Analysis of existing technologies for studying extracellular protein interactions.
Discussion of the role of the surfaceome in drug development.

Main Results:

The surfaceome is a critical component of cellular signaling networks.
66% of drugs in DrugBank target surfaceome proteins, underscoring their therapeutic relevance.
Understanding surfaceome organization and interactions is essential for overcoming in vitro-in vivo discrepancies.

Conclusions:

A deeper understanding of the surfaceome is needed to develop more effective drugs.
Studying the extracellular surfaceome interaction network offers promising avenues for diagnostics and therapeutics.
The surfaceome represents a rich target landscape for future drug discovery efforts.