Related Experiment Video

Updated: Feb 4, 2026

In vivo 19F MRI for Cell Tracking
10:05

In vivo 19F MRI for Cell Tracking

Published on: November 25, 2013

15.4K

Systemic Administration of Polyelectrolyte Microcapsules: Where Do They Accumulate and When? In Vivo and Ex Vivo

Nikita A Navolokin1,2, Sergei V German3,4, Alla B Bucharskaya5

  • 1Remote Controlled Theranostic Systems Lab, Saratov State University, Saratov 410012, Russia. nik-navolokin@yandex.ru.

Nanomaterials (Basel, Switzerland)
|October 13, 2018
PubMed

Insights

Biodegradable multilayer capsules containing iron oxide nanoparticles were injected into rats. These capsules degraded within 24 hours, showing safe, reversible organ changes and complete tissue restoration within a month, indicating potential for drug delivery.

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Pharmacology

Background:

  • Biodegradable polymers and iron oxide nanoparticles are explored for drug delivery.
  • Understanding the in vivo fate of such composite materials is crucial for safety and efficacy.

Purpose of the Study:

  • To investigate the biodistribution and degradation of multilayer capsules containing magnetite nanoparticles after intravenous injection in rats.
  • To assess the safety and reversibility of organ morphology following capsule administration.

Main Methods:

  • Intravenous injection of 4-micron multilayer capsules into rats.
  • In vivo tracking using magnetic resonance imaging (MRI).
  • Ex vivo analysis via histological examination (HE), atomic absorption spectroscopy (AAS), and electron spin resonance (ESR) at multiple time points (15 min to 30 days).

Main Results:

  • Capsules degraded within 24 hours, with iron oxide nanoparticles detectable up to 7 days in the liver and spleen.
  • Reversible morphological changes were observed in the kidney, heart, liver, and spleen.
  • Complete restoration of tissue morphology occurred one month post-injection.

Conclusions:

  • The composite microcapsules demonstrate a favorable biodistribution and degradation profile.
  • The observed reversible organ changes and complete tissue recovery suggest the safety of these microcapsules.
  • These findings support the potential use of these iron oxide-loaded biodegradable microcapsules as safe and effective drug delivery systems.
Keywords:
atomic absorption spectroscopybiodistributionelectron spin resonance spectroscopyhistological examinationintravenous injectionsmagnetic resonance imagingmagnetite nanoparticlespolymer microcapsules

More Related Videos

Simple and Effective Administration and Visualization of Microparticles in the Circulatory System of Small Fishes Using Kidney Injection13:28

Simple and Effective Administration and Visualization of Microparticles in the Circulatory System of Small Fishes Using Kidney Injection

Published on: June 17, 2018

8.9K
Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo12:19

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

11.3K

Related Concept Videos

Equivalence: In Vitro and In Vivo Bioequivalence01:17

Equivalence: In Vitro and In Vivo Bioequivalence

Body:Bioequivalence studies are crucial in evaluating whether new drugs can match an approved one regarding pharmacological effects and clinical performance. These studies test if drugs, despite different dosage forms, share identical plasma concentration-time profiles. Three types of equivalence are central to these studies: chemical, pharmaceutical, and therapeutic. Chemical equivalence indicates that two or more drug products contain identical active ingredients in equal amounts.
229
Second Order systems II01:18

Second Order systems II

In an underdamped second-order system, where the damping ratio ζ is between 0 and 1, a unit-step input results in a transfer function that, when transformed using the inverse Laplace method, reveals the output response. The output exhibits a damped sinusoidal oscillation, and the difference between the input and output is termed the error signal. This error signal also demonstrates damped oscillatory behavior. Eventually, as the system reaches a steady state, the error diminishes to zero.
408
First Order Systems01:21

First Order Systems

First-order systems, such as RC circuits, are foundational in understanding dynamic systems due to their straightforward input-output relationship. Analyzing their responses to different input functions under zero initial conditions reveals significant insights into system behavior.
When a first-order system is subjected to a unit-step input, its response is characterized by its transfer function. By applying the Laplace transform of the unit-step input to the transfer function, expanding the...
429
Second Order systems I01:20

Second Order systems I

A servo system exemplifies a second-order system, featuring a proportional controller and load elements that ensure the output position aligns with the input position. The relationship between these components is described by a second-order differential equation. Applying the Laplace transform under zero initial conditions yields the transfer function, showing how inputs are converted to outputs in the system.
By reinterpreting the system, one can derive the closed-loop transfer function, which...
598
Drug Product Performance: In Vitro–In Vivo Correlation01:20

Drug Product Performance: In Vitro–In Vivo Correlation

In pharmaceutical development, it's crucial to establish a predictive in vitro–in vivo correlation (IVIVC) for two or more formulations to gain a comprehensive understanding of release properties. IVIVC reduces the need for costly in vivo studies and facilitates the establishment of meaningful dissolution specifications with significant cost savings and decreased regulatory burden. Furthermore, a meaningful IVIVC should predict Cmax and AUC within 20%, aligning with FDA guidance while...
276
Thermodynamic Systems01:06

Thermodynamic Systems

A thermodynamic system is a set of objects whose thermodynamic properties are of interest. The system is considered to be embedded in its surroundings or the environment. The system and its environment can exchange heat and do work on each other through a boundary that separates them. However, the immediate surroundings of the system interact with it directly and therefore have a much stronger influence on its behavior and properties.
Consider an example of  tea boiling in a kettle. The...
8.0K