Related Experiment Video
Updated: Feb 4, 2026
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Design and methodology of the screening for CKD among older patients across Europe (SCOPE) study: a multicenter
Andrea Corsonello1, Lisanne Tap2, Regina Roller-Wirnsberger3
1Italian National Research Center on Aging (INRCA), Ancona, Fermo and Cosenza, Italy.
Insights
This study assesses kidney function in older adults using current methods and novel biomarkers. Findings will inform European guidelines for screening and managing chronic kidney disease (CKD) in the elderly.
Area of Science:
- Gerontology
- Nephrology
- Epidemiology
Background:
- Chronic kidney disease (CKD) prevalence increases with age, posing a significant health burden.
- Accurate assessment of kidney function in older adults is challenging due to limitations of current creatinine-based equations.
- CKD impacts various health outcomes, including morbidity and mortality, in the elderly population.
Purpose of the Study:
- To evaluate kidney function in individuals aged 75+ using established CKD screening methods.
- To investigate novel and existing biomarkers for CKD detection in this cohort.
- To correlate laboratory and biomarker results with comprehensive geriatric and functional data.
Main Methods:
- Prospective, multinational, multicenter observational cohort study of 2450 community-dwelling individuals aged 75 years and over.
- Baseline and 24-month follow-up with clinical evaluations, including comprehensive geriatric assessment (CGA), and laboratory tests.
- Centralized biomarker assessment alongside local laboratory analysis of standard parameters; intermediate telephone follow-ups at 6 and 18 months.
Main Results:
- N/A - Results not yet available in the provided abstract.
Conclusions:
- The SCOPE study aims to provide evidence for developing European guidelines on CKD screening and management in older individuals.
- Integration of CGA and novel biomarkers is expected to enhance the understanding and care of elderly patients with CKD.
- This research addresses a critical gap in accurately assessing and managing kidney function decline in an aging global population.
Background:
Decline of renal function is common in older persons and the prevalence of chronic kidney disease (CKD) is rising with ageing. CKD affects different outcomes relevant to older persons, additionally to morbidity and mortality which makes CKD a relevant health burden in this population. Still, accurate laboratory measurement of kidney function is under debate, since current creatinine-based equations have a certain degree of inaccuracy when used in the older population. The aims of the study are as follows: to assess kidney function in a cohort of 75+ older persons using existing methodologies for CKD screening; to investigate existing and innovative biomarkers of CKD in this cohort, and to align laboratory and biomarker results with medical and functional data obtained from this cohort. The study was registered at ClinicalTrials.gov, identifier NCT02691546, February 25th 2016.
Methods/Design:
An observational, multinational, multicenter, prospective cohort study in community dwelling persons aged 75 years and over, visiting the outpatient clinics of participating institutions. The study will enroll 2450 participants and is carried out in Austria, Germany, Israel, Italy, the Netherlands, Poland and Spain. Participants will undergo clinical and laboratory evaluations at baseline and after 12 and 24 months- follow-up. Clinical evaluation also includes a comprehensive geriatric assessment (CGA). Local laboratory will be used for 'basic' parameters (including serum creatinine and albumin-to-creatinine ratio), whereas biomarker assessment will be conducted centrally. An intermediate telephone follow-up will be carried out at 6 and 18 months.
Discussion:
Combining the use of CGA and the investigation of novel and existing independent biomarkers within the SCOPE study will help to provide evidence in the development of European guidelines and recommendations in the screening and management of CKD in older people.
Trial Registration:
This study was registered prospectively on the 25th February 2016 at clinicaltrials.gov ( NCT02691546 ).
More Related Videos
10:42Design to Implementation Study for Development and Patient Validation of Paper-Based Toehold Switch Diagnostics
Published on: June 17, 2022
08:18Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions
Published on: October 4, 2024
Related Concept Videos
01:11Observational Studies
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
01:15Bioavailability Study Design: Healthy Subjects Versus Patients
01:15Study Design in Statistics
Does aspirin reduce the risk of heart attacks? Is one brand of fertilizer more effective at growing roses than another? Is fatigue as dangerous to a driver as the influence of alcohol? Questions like these are answered using randomized experiments with proper...
01:20Study Designs in Epidemiology
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
01:11Bioavailability Study Design: Single Versus Multiple Dose Studies
01:17The Scope of Physics