Surgical resection for recurrent retroperitoneal leiomyosarcoma and liposarcoma

Area of Science:

• Oncology
• Surgical Oncology
• Cancer Research

Background:

• Retroperitoneal soft tissue sarcomas (STS) are rare, with high recurrence rates.
• The University of Maryland Medical Center (UMMC) serves a diverse patient population for STS treatment.

Purpose of the Study:

• To review UMMC's treatment experience with retroperitoneal STS.
• To analyze outcomes for liposarcoma (LPS) and leiomyosarcoma (LMS) patients.

Main Methods:

• Retrospective review of 49 patients with LPS or LMS treated 2000-2013.
• Kaplan-Meier plots and log-rank tests used for survival analysis (PFS, OS).

Main Results:

• Median overall survival (OS) was 6.3 years; 2-year OS rate was 81%.
• Median progression-free survival (PFS) was 1.8 years; 2-year PFS rate was 45%.
• Leiomyosarcoma showed higher incidence in African Americans; liposarcoma in Caucasians. OS and PFS influenced by AJCC stage, grade, tumor size, and resection extent.

Conclusions:

• Leiomyosarcoma may be more common in African Americans.
• Grade, tumor size, AJCC stage, histology, and resection extent are critical prognostic factors for retroperitoneal STS.
• Further research into biological features of LPS and LMS is warranted.