Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biofiltration with bicarbonate as dialysate buffer.

S Rizzelli, L Alfonso, C Corlianò

    The International Journal of Artificial Organs
    |December 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Transcriptomic profiling of milk fat globules in cows with different β-casein genotypes.

    Scientific reports·2025
    Same author

    Oral bisphosphonate-induced osteonecrosis complications in patients undergoing tooth extraction: a systematic review and literature updates.

    European review for medical and pharmacological sciences·2023
    Same author

    Development of a duplex qPCR assay with locked nucleic acid probes for A, B and E kappa-casein variants detection.

    Scientific reports·2022
    Same author

    A telemedicine-based approach with real-time transmission of blood glucose data improves metabolic control in insulin-treated diabetes: the DIAMONDS randomized clinical trial.

    Journal of endocrinological investigation·2022
    Same author

    Oral administration of nucleotides in calves: Effects on oxidative status, immune response, and intestinal mucosa development.

    Journal of dairy science·2022
    Same author

    Narrow single tooth implants for congenitally missing maxillary lateral incisors: a 5-year follow-up.

    Journal of biological regulators and homeostatic agents·2020
    Same journal

    Therapeutic plasma exchange added to CRRT combined with hemoperfusion in wasp sting-associated AKI: A multicenter retrospective cohort study.

    The International journal of artificial organs·2026
    Same journal

    Development of an early prediction model for ICU-acquired weakness in sepsis using PNI and SII.

    The International journal of artificial organs·2026
    Same journal

    Foot care behaviors and perceived exercise benefits and barriers in diabetic hemodialysis patients.

    The International journal of artificial organs·2026
    Same journal

    First clinical experience with citrate-anticoagulated CVVHD-based low-flow ECCO<sub>2</sub>R in severe hypercapnic respiratory failure.

    The International journal of artificial organs·2026
    Same journal

    Carboxyhemoglobin levels for the detection of hemolysis in patients supported by left ventricular assist devices: A case series.

    The International journal of artificial organs·2026
    Same journal

    Evaluation of arteriovenous fistulas of obtuse anastomosis in reducing thrombosis using computational fluid dynamics.

    The International journal of artificial organs·2026
    See all related articles

    Bicarbonate biofiltration (BiBF) offers a comparable alternative to standard hemodialysis for cardiovascular stability and waste removal. BiBF effectively corrects metabolic acidosis without the risk of hypocapnia seen with standard bicarbonate buffering.

    Area of Science:

    • Nephrology
    • Renal Replacement Therapy
    • Biocompatibility

    Background:

    • Metabolic acidosis is a common complication in patients undergoing intermittent hemodialysis.
    • Standard biofiltration (BF) uses bicarbonate buffering but can lead to complications like hypocapnia.
    • Bicarbonate biofiltration (BiBF) is an alternative buffering strategy for hemodialysis.

    Purpose of the Study:

    • To compare the efficacy and safety of bicarbonate biofiltration (BiBF) versus standard biofiltration (BF) in patients on intermittent renal replacement therapy (RDT).
    • To investigate the impact of BiBF on cardiovascular stability, waste molecule clearance, and acid-base balance.

    Main Methods:

    • A crossover study involving 10 patients on RDT, with each patient treated for 10 months on standard BF and 10 months on BiBF.

    Related Experiment Videos

  • Dialysis protocol: 3 hours every other day, with fluid infusion between 3 and 5 liters.
  • Sodium bicarbonate (100 mEq/h) was infused during BF. Cardiovascular stability, waste molecules, and acid-base balance were monitored.

    • Main Results:

    • No significant differences were observed in cardiovascular stability between BiBF and standard BF.
    • Waste molecule concentrations showed no significant changes across both protocols.
    • Both BiBF and standard BF effectively corrected metabolic acidosis. However, 50% of patients experienced acute hypocapnia at the end of standard BF sessions.

    Conclusions:

    • Bicarbonate biofiltration (BiBF) is a safe and effective alternative to standard biofiltration (BF) for patients on intermittent renal replacement therapy.
    • BiBF demonstrates comparable efficacy in maintaining cardiovascular stability and clearing waste molecules.
    • BiBF avoids the risk of acute hypocapnia associated with standard bicarbonate buffering during hemodialysis.